Malignant tumors arising in endometriosis: clinical-pathological study and flow cytometry analysis

Fishman A, A Fishman, Amiram Fishman, Dilaver Demırel, D Demirel, Demirel D, Laucirica R, Rodolfo Laucirica, R Laucirica, I Ramzy, Ramzy I, Ibrahim Ramzy, Tomas Klima, Klima T, T Klima, Lyzak J, Judy Lyzak, J Lyzak, A L Kaplan, Alan L. Kaplan, Kaplan AL
European journal of obstetrics, gynecology, and reproductive biology · 1996 · vol. 70(1) , pp. 69–74 · doi:10.1016/s0301-2115(96)02563-8 · PMID:9031923 · W2032934764
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This clinical-pathological study analyzed malignant tumors arising in endometriosis using flow cytometry to characterize their cellular properties.

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Abstract

BACKGROUND: Malignant transformation to endometriosis is a well documented phenomenon that occurs most commonly in the ovaries with cancer arising in extra-ovarian endometriosis being a rare event. METHODS: A retrospective clinical-pathological evaluation of eleven cases with malignant tumors arising in endometriosis was performed to evaluate the prognostic impact of various factors. Nuclear DNA content (ploidy) was assessed through flow cytometric study. RESULTS: Ovarian origin was identified in eight cases and three were associated with extra-ovarian endometriosis. Histologic type was endometrioid carcinoma in ten patients. The eleventh case had high grade endometrial stromal sarcoma. All tumors were diploid with no relation to stage, grade, or clinical outcome. The S-phase fraction (SPF) was analyzed in nine patients and no correlation could be demonstrated with any histologic parameters or clinical outcome. CONCLUSIONS: The DNA content seems to have no association with the classical prognostic parameters in these cases.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genital Neoplasms, Female Adult Adult Aged Aged Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Cell Transformation, Neoplastic Cell Transformation, Neoplastic DNA DNA DNA Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (44)

Cited by (14)

Source provenance

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License: CC0 · commercial use OK