Endometrioid adenocarcinoma arising from adenomyosis: report and immunohistochemical analysis of an unusual case

Sasaki T, T Sasaki, Toshiki Sasaki, Tatsuo Sugiyama, Sugiyama T, T Sugiyama, H Nanjo, Hiroshi Nanjo, Nanjo H, Naoto Hoshi, Hoshi N, N Hoshi, M. Murakami, Masayo Murakami, Murakami M, Akihiro Sugita, Sugita A, A Sugita, Takahashi M, Masato Takahashi, M Takahashi, Kawamura K, Koichi Kawamura, K Kawamura, Iwao Ono, Ono I, I Ono, H Masuda, Hirotake Masuda, Masuda H
Pathology international · 2001 · vol. 51(4) , pp. 308–313 · doi:10.1046/j.1440-1827.2001.01200.x · PMID:11350616 · W2154288163
Case report OA: closed CC0 ⤵ 18 in-corpus citations
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This report details an unusual case of endometrioid adenocarcinoma arising from adenomyosis in a 53-year-old woman, confirmed by histology and immunohistochemistry.

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Abstract

A case of endometrioid adenocarcinoma arising from adenomyosis is reported. The patient was a 53-year-old woman who complained of vulvar itching. Smear cytology of the endometrium revealed adenocarcinoma. Magnetic resonance imaging of the pelvis revealed a lesion with a slightly high intensity in the uterine fundus on a T2-weighted image. Semiradical total hysterectomy and bilateral adnexectomy were performed, followed by chemotherapy. Histologically, the lesion in the uterine fundus was composed mostly of adenocarcinoma with stromal invasion. There were many adenomyotic foci in and around the carcinoma, including some showing transition to adenocarcinoma. There was no malignant finding in the normally situated endometrium. The carcinoma invaded in the myometrium, involving the uterine serosa, but no dissemination to the peritoneal cavity was found. The carcinoma was, therefore, considered to be endometrioid adenocarcinoma arising from adenomyosis. Immunohistochemistry showed expression of p53 oncoprotein and Ki-67 antigen in the carcinoma cells. The value of immunohistochemistry in predicting prognosis is discussed.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenocarcinoma Endometrial Neoplasms Endometriosis Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Female Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (19)

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