Expression of interleukin-8 and monocyte chemotactic protein-1 in adenomyosis

E. Cagnur Ulukus, Ulukus EC, Ulukus M, Murat Ulukus, Murat Ulukuş, Seval Y, Yasemin Seval, Zheng W, Wenxin Zheng, Arici A, Aydin Arici, Aydın Arıcı
Human Reproduction · 2005 · vol. 20(10) , pp. 2958–2963 · doi:10.1093/humrep/dei154 · PMID:15979992 · W2155026951
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Adenomyosis foci and eutopic endometrium in the secretory phase showed altered expression of IL-8 and MCP-1 compared to normal endometrium.

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Abstract

BACKGROUND: To clarify the inflammatory nature of adenomyosis, we aimed to investigate the expression of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) by immunohistochemistry to determine their putative role in pathophysiology of adenomyosis. METHODS: Adenomyosis samples, with their eutopic endometrium, were collected from 30 women undergoing hysterectomy. Endometrium from 27 women without adenomyosis were also collected as a control group. Samples were grouped according to the menstrual cycle phase and examined by immunohistochemistry for IL-8 and MCP-1. RESULTS: In normal endometrium, secretory phase samples expressed higher levels of epithelial IL-8 than in proliferative phase samples (P = 0.01), and we observed a trend for an increased epithelial MCP-1 expression in the secretory phase samples compared with the proliferative phase samples (P = 0.07). Endometrial samples of women with adenomyosis did not show the same cyclic variation. In the secretory phase, eutopic endometrium of women with adenomyosis expressed lower levels of epithelial IL-8 and MCP-1 compared with normal endometrium (P < 0.05). The expression of epithelial IL-8 and MCP-1 was higher in the adenomyosis foci than the eutopic endometrium (P < 0.05). CONCLUSIONS: These findings may indicate that an intrinsic abnormality of inflammatory response may be present in eutopic endometrium of women with adenomyosis, and IL-8 and MCP-1 may contribute to the pathophysiology of adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Chemokine CCL2 Endometriosis Gene Expression Regulation Gene Expression Regulation Interleukin-8 Adult Adult Chemokine CCL2 Chemokine CCL2 Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Female Humans Humans Hysterectomy

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References (29)

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