The differential expression of mRNAs and long noncoding RNAs between ectopic and eutopic endometria provides new insights into adenomyosis

Cheng Zhou, Ting Zhang, Fei Liu, Ji Zhou, Xiaobei Ni, Ran Huo, Zhonghua Shi
Molecular bioSystems · 2015 · vol. 12(2) , pp. 362–370 · doi:10.1039/c5mb00733j · PMID:26662114 · W2196379591
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This study compared mRNA and lncRNA expression in ectopic versus eutopic endometria from adenomyosis patients, identifying differential expression and potential molecular abnormalities.

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Abstract

Adenomyosis, defined as ectopic endometrial tissue within the myometrium, can often be misdiagnosed as multiple uterine leiomyomata or endometrial thickening. We therefore performed a combined mRNA and long noncoding (lnc)RNA microarray and bioinformatic analysis of eutopic and ectopic endometria in women with adenomyosis to better understand its pathogenesis and help in the development of a semi-invasive diagnostic test. A total of 586 mRNAs were increased and 305 mRNAs decreased in the ectopic endometrium of adenomyosis compared with the eutopic endometrium, while 388 lncRNA transcripts were up-regulated and 188 down-regulated in ectopic compared with paired eutopic endometrial tissue. Bioinformatic analysis suggested a series of metabolic and molecular abnormalities in adenomyosis, which have many similarities with endometriosis. Furthermore, our study constitutes the first known report of lncRNA expression patterns in human adenomyosis ectopic and eutopic endometrial tissue.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyosis Endometrium RNA, Long Noncoding RNA, Messenger Adenomyosis Adenomyosis Adult Biomarkers Biomarkers Endometrium Endometrium Female Gene Expression Gene Ontology Humans Middle Aged RNA, Long Noncoding RNA, Long Noncoding RNA, Messenger RNA, Messenger

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (51)

Cited by (23)

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