Steroid Receptors in the Uterus: Implications in Endometriosis

Moutsatsou P, Paraskevi Moutsatsou, P Moutsatsou, C E Sekeris, Sekeris CE
Annals of the New York Academy of Sciences · 2003 · vol. 997(1) , pp. 209–222 · doi:10.1196/annals.1290.024 · PMID:14644828 · W2059583173
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This paper reviews steroid receptor genes, protein structure, modes of action, uterine physiology roles, and their potential link to endometriosis based on polymorphisms and receptor changes.

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Abstract

Receptor proteins for estrogens, progesterone, androgens, and glucocorticoids have been detected in the various cell types of the uterus. Reference is made to the genes encoding these receptors, to the structure of the receptor proteins, and their functional domains. The mode of action of steroid hormones by gene activation, through their cognate receptors, and by nongenomic effects is briefly presented. The role of the steroid receptors in uterine physiology and the significance of the use of steroid receptor knock-out animals in delineating the in vivo action of the hormones is discussed. Recent results on the possible correlation of steroid receptor gene polymorphisms and of quantitative and qualitative changes in the receptor proteins to the etiopathology of endometriosis are reviewed.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Receptors, Steroid Uterus Binding Sites Biological Transport Endometriosis Endometriosis Female Humans Prognosis Receptors, Androgen Receptors, Androgen Receptors, Estrogen Receptors, Estrogen Receptors, Glucocorticoid Receptors, Glucocorticoid Receptors, Progesterone Receptors, Progesterone Receptors, Steroid Risk Assessment

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (90)

Cited by (14)

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europepmc
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License: CC0 · commercial use OK