Parametrial and rectovaginal adenocarcinoma arising from endometriosis
Case report
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⤵ 39 in-corpus citations
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This paper describes two cases of adenocarcinoma originating from endometriosis in the parametrial and rectovaginal regions.
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Abstract
Malignant extragonadal tumors arising from endometriosis are rare. We report on two cases. A 41-year-old gravida 1, para 1 (G1P1), with adenocarcinoma of the right parametrium arising from endometriosis and a 51-year-old G1P1 with endometriosis-associated rectovaginal adenocarcinoma were treated. Treatment included radical surgery plus radiation therapy. While the former patient was doing well 2 years after the primary diagnosis, the latter suffered a local pelvic recurrence 2 years later. Although there are no randomized controlled studies, radical surgery followed by radiation therapy seems generally to be the treatment of choice. The analysis of PTEN in various forms of endometriosis and its malignant transformation may help in understanding the early steps of tumorigenesis.
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Cited by (38)
- Case Report: Malignant transformation of deep infiltrating endometriosis: a report of two cases and literature review 2026
- The "Road" to Malignant Transformation from Endometriosis to Endometriosis-Associated Ovarian Cancers (EAOCs): An mTOR-Centred Review 2024
- "Uterine-type" Extra-uterine High-grade Sarcoma of the Rectovaginal Septum: Case Report and Review of Literature 2024
- Genetic Links between Endometriosis and Endometriosis-Associated Ovarian Cancer-A Narrative Review (Endometriosis-Associated Cancer) 2024
- Endometrioid adenocarcinoma of the colon arising from rare malignant transformation of extra-gonadal endometrioma 2024
- A Case of a Retroperitoneal Tumor with a Histological Picture Suggestive of Malignant Transformation Resulting from Endometriosis 2023
- A case of polypoid endometriosis mimicking advanced ovarian carcinoma with rapid growth, invasion, and dissemination 2022
- Difficulties in Differentiation of Malignant Neoplasms and Deep Infiltrative Endometriosis 2022
- Malignancy Risks Associated with Endometriosis: Clinical Aspects 2022
- Postmenopozal ovarian endometrioma kaynaklı yüksek dereceli over seröz karsinomu: Nadir Görülen Bir Olgu 2022
- Malignant endometriosis-associated ovarian and extraovarian neoplasia (review of literature) 2022
- Malignant extra-ovarian endometriosis: A case series of ten patients and review of the literature 2020
- Occurrence of seromucinous borderline tumours in the peritoneal lesions after bilateral salpingo-oophorectomy 2020
- Rectovaginal septum primary squamous cell cancer: Extremely rare entity 2020
- A case of cervical adenocarcinoma arising from endometriosis in the absence of human papilloma virus infection 2019
- Extragonadal Giant Endometrial Cyst with Endometrioid Borderline Tumor 2019
- High-Grade Serous Carcinoma Resulting From Rectal Endometriosis and Complicated With Ovarian Cancer 2019
- Endometriosis-associated malignant tumors associated with deep infiltrative endometriosis: review of the literature and clinical observations 2019
- Laparoscopic posterior pelvic exenteration for primary adenocarcinoma of the rectovaginal septum without associated endometriosis: A case report 2018
- Endometriose — ein Überblick 2017
- Endometriosis-associated Malignancy 2016
- Malignome auf dem Boden einer Endometriose 2016
- Endometrioseassoziierte maligne Tumoren 2015
- A Case of Endometrioid Adenocarcinoma Originating from the Serous Surface of the Small Intestine 2015
- A Case of Ileal Endometriosis with Lymph-node Involvement Presented with Small Bowel Obstruction 2014
- National German Guideline (S2k): Guideline for the Diagnosis and Treatment of Endometriosis: Long Version - AWMF Registry No. 015-045 2014
- Endometrioid adenocarcinoma arising from abdominal wall endometriosis in the appendectomy scar: A case report 2013
- Disseminated peritoneal leiomyomatosis with endometriosis 2012
- Diagnostik und Therapie der Endometriose 2012
- Mixed adenocarcinoma of the rectovaginal septum associated with endometriosis and endometrial carcinoma: a case report 2011
- An investigation of the surgical treatment of endometriosis 2010
- Primary adenocarcinoma of the rectovaginal septum without associated endometriosis 2010
- Carcinoma of müllerian origin presenting as colorectal cancer: a clinicopathologic study of 13 Cases 2010
- Gamma-ray energy absorption and exposure buildup factor studies in some human tissues with endometriosis 2010
- Immunohistochemical evaluation of endometriotic lesions and disseminated endometriosis-like cells in incidental lymph nodes of patients with endometriosis 2009
- [Primary adenocarcinoma of the rectovaginal septum without associated endometriosis] 2008
- Estrogen and progestogen receptor positive endometriotic lesions and disseminated cells in pelvic sentinel lymph nodes of patients with deep infiltrating rectovaginal endometriosis: a pilot study 2008
- Endometriosis: A general review and rationale for surgical therapy 2006
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- europepmc
- last seen: 2026-10-12T06:17:10.165071+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:03:30.943773+00:00
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