Endometriosis-associated ovarian cancer is a single entity with distinct clinicopathological characteristics

Qianwen Li, Li Q, Yue Sun, Xiang Zhang, Zhang X, Wang L, Linping Wang, Wu W, Wenling Wu, Wu M, Meijing Wu, Chao Meng, Meng C, Guoyan Liu
Cancer biology & therapy · 2019 · vol. 20(7) , pp. 1029–1034 · doi:10.1080/15384047.2019.1595278 · PMID:30913953 · PMC6605994 · W2924316731
Observational OA: bronze CC0 ⤵ 20 in-corpus citations
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Endometriosis-associated ovarian cancer presents in younger patients at earlier stages and is linked to nulliparity/infertility, showing a better prognosis likely due to early-stage presentation rather than endometriosis itself.

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Abstract

Objective: To compare the clinicopathological features and chemotherapy response of ovarian clear cell carcinoma (CCC) and endometrioid carcinoma (EC) associated with endometriosis or not. Methods: This was a retrospective study of 128 patients diagnosed with CCC and EC from 2002 to 2017. Clinicopathological features and chemotherapy response were analyzed. Results:There were 34 women with endometriosis-associated ovarian cancer (EAOC) and 94 with non-endometriosis associated ovarian cancer (non-EAOC) according to Sampson's and Scott's criteria. The mean diagnosis age in the EAOC group was 48.65 vs. 54.39 years in non-EAOC (p = 0.002). Compared with non-EAOC, the EAOC patients were more likely to have an earlier menarche age (13 vs. 14 years, p = 0.001), a higher incidence of infertility (26.47% vs. 10.64%, p = 0.026), and an earlier stage tumor (91.18% vs. 73.40% in stages I-II, p = 0.032). At a median follow-up time of 32.9 months, overall survival among patients with EAOC was significantly longer (109.8 vs. 47.4 months, p = 0.007). Association with endometriosis (p = 0.033) was the significant favorable prognostic factors associated with survival. However, stratifying by stage, the overall survival advantage of EAOC was not significant. Although EAOC had a better prognosis, no difference was observed in chemotherapy response between the two groups (p = 0.535). Conclusions: The EAOC patients were often diagnosed at a younger age, an earlier stage, and related to nulliparity and infertility. Patients with EAOC had a better prognosis than non-EAOC, early stage rather than association with endometriosis may be the driver of survival.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Ovarian Neoplasms Ovarian Neoplasms Adult Adult Aged Aged Antineoplastic Combined Chemotherapy Protocols Antineoplastic Combined Chemotherapy Protocols Antineoplastic Combined Chemotherapy Protocols Disease Susceptibility Disease Susceptibility Drug Resistance, Neoplasm Drug Resistance, Neoplasm Endometriosis Endometriosis Female Female Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (24)

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