The vascular endothelial growth factor +405G>C polymorphism in endometriosis

Davide Gentilini, Edgardo Somigliana, Paola Viganò, Paola Vigano, Michele Vignali, M. Vignali, Mauro Busacca, Busacca M, Di Blasio AM, A. M. Di Blasio, Anna Maria Di Blasio
Human Reproduction · 2007 · vol. 23(1) , pp. 211–215 · doi:10.1093/humrep/dem341 · PMID:17977866 · W2100780765
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This study investigated the VEGF +405G>C polymorphism in Italian women, finding a significant association with endometriosis risk, but meta-analysis revealed heterogeneity among studies.

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Abstract

BACKGROUND: Vascular endothelial growth factor (VEGF) is a potent stimulus of angiogenesis potentially contributing to the pathogenesis of endometriosis. The aim of this study was to investigate the potential association between the single nucleotide polymorphism +405G>C of the VEGF gene with the risk of endometriosis, for the first time in the Caucasian population. METHODS: The polymorphism +405G>C of the VEGF gene was examined in n = 203 Italian women affected by endometriosis and in n = 140 women without laparoscopic evidence of the disease. All the women were genotyped by PCR-restriction fragment length polymorphism from venous blood samples. We then performed a meta-analysis including results from the present study and from the two previously published studies on this topic. RESULTS: The distribution of the three different genotypes significantly differed between women with and without the disease (P = 0.03). The odds ratio (95% confidence interval) for endometriosis in women carrying the C allele was 1.8 (1.2-2.8). The Breslow-Day test revealed statistically significant heterogeneity among the studies performed so far thus indicating inconsistency among studies and excluding the possibility of obtaining a common estimation of the effect. CONCLUSIONS: Results obtained herein are in keeping with those obtained previously and support a role for the +405G>C VEGF polymorphism in endometriosis development, although a further, larger study is required to confirm our findings. However, this effect may depend on the population studied. Ethnicity and the characteristics of endometriosis are likely to influence this association.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Polymorphism, Genetic Polymorphism, Genetic Vascular Endothelial Growth Factor A Adult Adult Alleles Alleles Cytosine Cytosine Endometriosis Endometriosis Female Female Genetic Heterogeneity Genetic Heterogeneity Genetic Predisposition to Disease Genetic Predisposition to Disease Genotype Genotype

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (22)

Cited by (29)

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