Levonorgestrel-releasing intrauterine device in the treatment of menorrhagia
Non-randomised trial
OA: closed
CC0
⤵ 71 in-corpus citations
AI-generated summary
This study found that a levonorgestrel-releasing intrauterine device significantly reduced menstrual blood loss by 86% after 3 months and 97% after 12 months in 20 women with menorrhagia.
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Abstract
In 20 women with menorrhagia (greater than 80 ml blood loss per menstrual period) a levonorgestrel-releasing intrauterine device (Lng-IUCD) was inserted. Menstrual blood loss (MBL) was measured in two consecutive cycles before the device was inserted and after 3, 6 and 12 months of use. MBL was significantly reduced after 3 months (86%) and after 12 months the reduction was 97%. There was a significant increase (P less than 0.001) in serum ferritin during the first year of Lng-IUCD use. The Lng-IUCD seems to be an important alternative to oral medication and to hysterectomy in the treatment of menorrhagia.
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- Intrauterine Devices: Effective Contraception with Noncontraceptive Benefits for Adolescents 2019
- The current status of hormonal therapies for heavy menstrual bleeding 2017
- Non-contraceptive benefits of intrauterine levonorgestrel administration: why not? 2017
- Medical management of heavy menstrual bleeding: a comprehensive review of the literature 2015
- Different bleeding patterns with the use of levonorgestrel intrauterine system: are they associated with changes in uterine artery blood flow? 2014
- Noncontraceptive benefits of the estradiol valerate/dienogest combined oral contraceptive: a review of the literature 2014
- Use of levonorgestrel intrauterine system for medical indications in adolescents 2013
- Are women satisfied when using levonorgestrel-releasing intrauterine system for treatment of abnormal uterine bleeding? 2013
- TO DETERMINE THE USE OF AN LNG-IUS FOR CONSERVATIVE MANAGEMENT IN WOMEN WITH SYMPTOMATIC MILD TO MODERATE ENDOMETRIOSIS 2013
- Added health benefits of the levonorgestrel contraceptive intrauterine system and other hormonal contraceptive delivery systems 2012
- Pharmacological therapy for abnormal uterine bleeding 2011
- Progesterone: a pivotal hormone at menstruation 2011
- Use of the levonorgestrel-releasing intrauterine system, quality of life and sexuality. Experience in an Italian family planning center 2011
- Heavy menstrual bleeding: considering the most effective treatment option 2011
- Non-contraceptive applications of the levonorgestrel intrauterine system 2010
- Effectiveness and safety of Levonorgestrel Releasing IntrauterineSystem in treatment of menorrhagia secondary to oral anticoagulationsand chronic liver disease 2009
- Levonorgestrelį išskiriančios gimdos spiralės vartojimas ginekologijoje 2009
- Intrauterine progestins, progesterone antagonists, and receptor modulators: a review of gynecologic applications 2009
- The levonorgestrel intrauterine system (Mirena) for treatment of idiopathic menorrhagia. Assessment of quality of life and satisfaction 2008
- Levonorgestrel-releasing intrauterine system: uses and controversies 2008
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- [Medical treatment of idiopathic menorrhagia] 2008
- Medical therapies for chronic menorrhagia 2007
- Progesterone receptor modulators and the endometrium: changes and consequences 2007
- An important Finnish contribution to the advancement of women's reproductive health 2007
- Health status function after treatment with thermal balloon endometrial ablation and levonorgestrel intrauterine system for idiopathic menorrhagia: a randomized study 2006
- Endometrial adenocarcinoma in association with a levonorgestrel-releasing intrauterine system (Mirena) 2006
- The effect of levonorgestrel-releasing intrauterine system use on menstrual blood loss and the hemostatic, fibrinolytic/inhibitor systems in women with menorrhagia 2006
- Managing menorrhagia in primary care 2005
- Out-patient hysteroscopy: findings and decision making for treatment of abnormal uterine bleeding in pre- and post-menopausal women 2005
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- Correlation between endometrial histology, microvascular density and calibre, matrix metalloproteinase-3 and bleeding pattern in women using a levonorgestrel-releasing intrauterine system 2004
- Insertion of mirena after endometrial resection in patients with adenomyosis 2003
- Chemical ablation of endometrium with trichloroacetic acid 2003
- Current treatment of dysfunctional uterine bleeding 2003
- Impact of patient information booklet on treatment decision--a randomized trial among women with heavy menstruation 2003
- Update on treatment of menstrual disorders 2003
- Effects of levonorgestrel-releasing intra-uterine system on the expression of vascular endothelial growth factor and adrenomedullin in the endometrium in adenomyosis 2003
- The evaluation of the effectiveness of an intrauterine-administered progestogen (levonorgestrel) in the symptomatic treatment of endometriosis and in the staging of the disease 2003
- Efficacy of the levonorgestrel intrauterine system in treating menorrhagia: actualities and ambiguities 2002
- Gynecologic problems of the perimenopause: evaluation and treatment 2002
- Effects of the levonorgestrel-releasing intrauterine system on proliferation and apoptosis in the endometrium 2001
- A case notes analysis of hysterectomy performed for non-neoplastic indications at Liaquat National Hospital, Karachi 2001
- Treatment of menorrhagia with the levonorgestrel intrauterine system versus endometrial resection 2001
- Endometrial cryoablation and thermal ablation 2000
- Medical management of dysfunctional uterine bleeding 1999
- Intrauterine progestogens for management of menorrhagia 1998
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:08:28.697392+00:00
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