Endometrial adenocarcinoma in association with a levonorgestrel-releasing intrauterine system (Mirena)

Case report OA: bronze CC0 ⤵ 1 in-corpus citation
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-29 ⓘ

This report details a case of endometrial cancer in a postmenopausal woman using a levonorgestrel-releasing intrauterine system for menorrhagia, prompting discussion on management implications.

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Abstract

The levonorgestrel-releasing intrauterine system (LNGIUS) Mirena has been licensed as a contraceptive in the UK since 1995. In 2002 Mirena became licensed also for the management of idiopathic menorrhagia and in 2004 the product licence was extended further to use for protection to prevent endometrial hyperplasia in women receiving oestrogen replacement therapy. We report a case of primary endometrioid endometrial carcinoma diagnosed in a postmenopausal woman who had a LNG-IUS inserted 4 years previously for treatment of perimenopausal menorrhagia and we discuss the implications for management of women presenting with perimenopausal menorrhagia. (excerpt)

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MeSH descriptors

Adenocarcinoma Contraceptive Agents, Female Endometrial Neoplasms Intrauterine Devices, Medicated Levonorgestrel Adenocarcinoma Adenocarcinoma Contraceptive Agents, Female Endometrial Neoplasms Endometrial Neoplasms Female Humans Intrauterine Devices, Medicated Levonorgestrel Middle Aged

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openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:03:51.313027+00:00
License: CC0 · commercial use OK