Female infertility

Bhattacharya S, Siladitya Bhattacharya, Neil F. Johnson, Johnson N, Neil Johnson, Tijani HA, Hammed Akanji Tijani, Roger Hart, Hart R, Pandey S, Shilpi Pandey, Ahmed Fathy Gibreel, Ahmed Gibreel, Gibreel AF
BMJ clinical evidence · 2010 · vol. 2010 · PMID:21406133 · PMC3217752 · W4298065343
Systematic review / meta-analysis OA: closed CC0
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This systematic review evaluated the effectiveness and safety of various treatments for female infertility, including ovulation disorders, tubal infertility, endometriosis, and unexplained infertility.

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Abstract

INTRODUCTION: About 17% of couples in industrialised countries seek help for infertility, which may be caused by ovulatory failure, tubal damage or endometriosis, or a low sperm count. In developed countries, 80% to 90% of couples attempting to conceive are successful after 1 year and 95% after 2 years. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments for infertility caused by ovulation disorders? What are the effects of treatments for tubal infertility? What are the effects of treatments for infertility associated with endometriosis? What are the effects of treatments for unexplained infertility? We searched: Medline, Embase, The Cochrane Library, and other important databases up to October 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 55 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: clomifene; drug-induced ovarian suppression; gonadotrophin priming of oocytes before in vitro maturation; gonadotrophins; gonadotrophin-releasing hormone agonists plus gonadotrophins; gonadotrophin-releasing hormone antagonists; in vitro fertilisation; intrauterine insemination alone, or combined with gonadotrophins or clomifene; laparoscopic ablation of endometrial deposits; laparoscopic ovarian drilling; laparoscopic removal; metformin; ovarian wedge biopsy; pulsatile gonadotrophin-releasing hormone; selective salpingography plus tubal catheterisation; tamoxifen; tubal flushing; and tubal surgery before in vitro fertilisation.

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Condition tags

endometriosisinfertility

MeSH descriptors

Clomiphene Clomiphene Clomiphene Infertility, Female Infertility, Female Administration, Oral Administration, Oral Anovulation Anovulation Female Female Humans Humans Infertility Infertility Ovulation Induction Ovulation Induction Polycystic Ovary Syndrome Polycystic Ovary Syndrome

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (90)

Source provenance

europepmc
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License: CC0 · commercial use OK