Expression of Th1 and Th2 cytokine-associated transcription factors, T-bet and GATA-3, in the eutopic endometrium of women with endometriosis

Peng Chen, Chen P, Zhifang Zhang, Zhang Z, Chen Q, Qi Chen, Ren F, Fang Ren, Tong Li, Li T, Zhang C, Chiyuan Zhang, Wang D, Danbo Wang
Acta histochemica · 2012 · vol. 114(8) , pp. 779–784 · doi:10.1016/j.acthis.2012.01.005 · PMID:22356900 · W1971538041
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This study investigated the expression of T-bet and GATA-3 transcription factors, associated with Th1 and Th2 cytokines, within the eutopic endometrium of women diagnosed with endometriosis.

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Abstract

The objective of the present study was to evaluate the expression of T-box expressed in T cells (T-bet) and GATA binding protein 3 (GATA-3) in the eutopic endometrium from women with endometriosis. Endometrial tissues were collected from 20 women with laparoscopically confirmed endometriosis and 20 women without endometriosis. T-bet and GATA-3 expression was measured by quantitative real-time PCR (qPCR), immunohistochemistry and Western blot analysis. Eutopic endometrial tissues from patients with endometriosis expressed lower levels of T-bet mRNA and high levels of GATA-3 mRNA, leading to a significant lower T-bet/GATA-3 mRNA ratio (P<0.05). Western blot analysis showed that the T-bet/GATA-3 protein ratio in endometriosis group was also statistically lower than that in the control group (P<0.05). These results suggested that T-bet and GATA-3 may act as cytokine regulatory genes, and the Th2-specific transcription factor, GATA-3, probably plays an essential role in the immune response and the development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cytokines Endometriosis Endometrium GATA3 Transcription Factor GATA3 Transcription Factor T-Box Domain Proteins T-Box Domain Proteins Adult Adult Blotting, Western Blotting, Western Cytokines Cytokines Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (21)

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