Interleukin-2 receptor beta gene C627T polymorphism in Korean women with endometriosis: a case-control study

Lee GH, Gyoung Hoon Lee, Choi YM, Young Min Choi, Yun‐Shik Choi, Sung Hoon Kim, Min A Hong, Min Hong, Hong Ma, Seung Yup Ku, Ku SY, Seung‐Yup Ku, Se Hoon Kim, Seok Hyun Kim, Kim SH, Jung Gu Kim, J. G. Kim, Kim JG, Moon SY, Shin Yong Moon, Soo Young Moon
Human Reproduction · 2009 · vol. 24(10) , pp. 2596–2599 · doi:10.1093/humrep/dep242 · PMID:19602517 · W2140049848
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This case-control study found no association between the IL-2R beta C627T polymorphism and endometriosis risk in Korean women.

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Abstract

BACKGROUND: The purpose of this study was to investigate the potential association of the C627T polymorphism in the interleukin-2 receptor beta gene (IL-2R beta) with the risk of endometriosis in Korean women. METHODS: Two hundred and thirty-seven women with surgically or histologically diagnosed endometriosis of stages III and IV were recruited for this study, and 164 patients with no evidence of endometriosis diagnosed by laparoscopy or laparotomy served as controls. The C627T polymorphism of the IL-2R beta was assessed using the TaqMan allelic discrimination assay. Chi2 analysis was used to examine any differences in genotype distributions and allele frequencies of the IL-2R beta C627T polymorphism between the endometriosis cases and the controls. RESULTS: There was no statistically significant difference in the frequency of the IL-2R beta C627T polymorphism between the endometriosis patients and the controls (28.7% C/C, 48.1% C/T and 23.2% T/T versus 29.3, 44.5 and 26.2%, respectively, P = 0.72) or in the T allele frequencies (47.3 versus 48.5%, respectively, P = 0.73). Even when the endometriosis cases were subdivided into stages III and IV, no statistically significant differences in genotype distributions or allele frequencies were observed among the three groups. CONCLUSIONS: Contrary to the recent data reported in a Taiwanese population, our results suggest that the C627T polymorphism of the IL-2R beta gene may not be associated with the risk of endometriosis in the Korean population.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Interleukin-2 Receptor beta Subunit Polymorphism, Genetic Polymorphism, Genetic Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency Genotype Genotype Humans Humans Interleukin-2 Receptor beta Subunit Interleukin-2 Receptor beta Subunit

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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