Immunohistochemical analysis of insulin‐like growth factor I, insulin‐like growth factor I receptor and insulin‐like growth factor II in endometriotic tissue and endometrium

Chang SY, Shiuh Young Chang, S Y Chang, Ho YS, Yat‐Sen Ho, Y S Ho
Acta obstetricia et gynecologica Scandinavica · 1997 · vol. 76(2) , pp. 112–117 · doi:10.3109/00016349709050064 · PMID:9049281 · W2071187236
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Insulin-like growth factor I (IGF-I) and its receptor were detected similarly in both endometriotic and eutopic endometrial tissues, while insulin-like growth factor II (IGF-II) was minimally present in both.

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Abstract

BACKGROUND: The purpose of this study was to investigate unprecedentedly immunohistochemical localization of insulin-like growth factor I, insulin-like growth factor I receptor and insulin-like growth factor II in endometriotic tissue, and to compare staining intensity with that of endometrium obtained simultaneously. METHODS: Endometriotic and corresponding endometrial tissue samples were obtained during operative laparoscopy from eighteen infertile patients for the problem of infertility. Semiquantitative scoring was used for analysis of results. RESULTS: It was demonstrated that insulin-like growth factor I and insulin-like growth factor I receptor were present in both endometriotic and endometrial tissues. In contrast, there was little insulin-like growth factor II present in either ectopic or eutopic endometrial tissue. For insulin-like growth factor I and insulin-like growth factor I receptor, the immunostaining score was similar between ectopic and eutopic endometrial tissues. There was no significant difference in immunostaining score between glandular epithelium and stromal cells. CONCLUSIONS: insulin-like growth factor I and insulin-like growth factor I receptor could be demonstrated immunohistochemically in both endometriotic and endometrial tissues.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometrium Insulin-Like Growth Factor I Insulin-Like Growth Factor II Peritoneal Diseases Receptor, IGF Type 1 Adult Endometriosis Endometrium Female Humans Immunohistochemistry Insulin-Like Growth Factor I Insulin-Like Growth Factor II Peritoneal Diseases Receptor, IGF Type 1

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