Treg and NK cells related cytokines are associated with deep rectosigmoid endometriosis and clinical symptoms related to the disease

Bárbara Yasmin Gueuvoghlanian-Silva, Gueuvoghlanian-Silva BY, Bárbara Yasmin Gueuvoghlanian‐Silva, Bellelis P, Patrick Bellelis, Denise Frediani Barbeiro, Barbeiro DF, Hernandes C, Camila Hernandes, Sergio Podgaec, Sérgio Podgaec
Journal of Reproductive Immunology · 2018 · vol. 126 , pp. 32–38 · doi:10.1016/j.jri.2018.02.003 · PMID:29477012 · W2793621309
article OA: green CC0 ⤵ 32 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study investigated the association between cytokines produced by regulatory T cells and natural killer cells and deep rectosigmoid endometriosis, finding a correlation with disease presence and clinical symptoms.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The aim of this study was to evaluate Treg and NK cells related cytokines in deep infiltrating endometriosis lesions and its relationship with clinical symptoms of the disease. mRNA expression of Transforming Growth Factor Beta (TGFB), Interleukin (IL)10, Interferon Gamma (IFNG), IL7, and IL15 was analyzed by Real-Time PCR in eutopic endometrium and rectosigmoid lesions from 11 women with deep infiltrating endometriosis and in eutopic endometrium from 11 healthy women. IL10, IFNG, and IL7 expression was significantly higher in endometriotic bowel lesions than in eutopic endometrium from women with endometriosis. IL10 and TGFB expression was significantly higher in endometriotic bowel lesions than in eutopic endometrium from healthy women. In addition, TGFB and IL15 levels correlated positively with deep dyspareunia and cyclic dyschezia, respectively, while IL7 levels correlated negatively with dysmenorrhea. Deep infiltrating rectosigmoid endometriosis displays alterations in Treg and NK cells related cytokine, and TGFB, IL7 and IL15 expression is related with dyspareunia, dysmenorrhea and cyclic dyschezia, respectively, in patients with the disease.

My notes (saved in your browser only)

Condition tags

dysmenorrheadyspareuniaendometriosis

MeSH descriptors

Choristoma Colon, Sigmoid Endometriosis Endometrium Killer Cells, Natural Rectum T-Lymphocytes, Regulatory Adolescent Adult Case-Control Studies Choristoma Colon, Sigmoid Constipation Cytokines Cytokines Dysmenorrhea Dyspareunia Endometriosis Endometrium Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (37)

Cited by (34)

Source provenance

europepmc
last seen: 2026-10-08T06:18:23.926119+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:19:55.107525+00:00
License: CC0 · commercial use OK