Foxp3 expression in deep rectosigmoid endometriosis lesions and its association with chronic pelvic pain

Sergio Podgaec, Sérgio Podgaec, Denise Frediani Barbeiro, Barbeiro DF, Bárbara Yasmin Gueuvoghlanian‐Silva, Gueuvoghlanian-Silva BY, Bárbara Yasmin Gueuvoghlanian-Silva, Patrick Bellelis, Bellelis P, Maurício Simões Abrão, Abrão MS, Edmund Chada Baracat, Baracat EC
Journal of Reproductive Immunology · 2014 · vol. 104-105 , pp. 96–99 · doi:10.1016/j.jri.2014.05.002 · PMID:25064223 · W2066482711
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This study investigated Foxp3 expression in deep rectosigmoid endometriosis lesions and its association with chronic pelvic pain in affected women.

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Abstract

Endometriosis is a benign gynecological disease that is related to immune response alterations. T regulatory cells modulate immune response, and Foxp3 seems to be the best marker of these cells. This study evaluated Foxp3 mRNA expression in eutopic endometrium from women with endometriosis and healthy controls, and its expression in deep rectosigmoid endometriosis lesions, one of the more aggressive types of the disease. Foxp3 expression was higher in lesions than in eutopic endometrium in the two groups. Moreover, eutopic endometrium Foxp3 expression of women with endometriosis was associated with chronic pelvic pain and cyclic urinary pain.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Chronic Pain Endometriosis Forkhead Transcription Factors Gene Expression Regulation Pelvic Pain Adolescent Adult Case-Control Studies Chronic Pain Chronic Pain Chronic Pain Endometriosis Endometriosis Endometriosis Female Forkhead Transcription Factors Forkhead Transcription Factors Gene Expression Regulation Humans Pelvic Pain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (13)

Cited by (16)

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