Plasminogen activator inhibitor-1 4G/5G polymorphism and susceptibility to endometriosis in the Italian population

Davide Gentilini, Paola Vigano, Paola Viganò, Davide Castaldi, Castaldi D, Daniela Mari, Busacca M, Mauro Busacca, Paolo Vercellini, Edgardo Somigliana, Di Blasio AM, Anna Maria Di Blasio
European journal of obstetrics, gynecology, and reproductive biology · 2009 · vol. 146(2) , pp. 219–221 · doi:10.1016/j.ejogrb.2009.06.008 · PMID:19608328 · W2013604702
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This study investigated the association between the plasminogen activator inhibitor-1 4G/5G polymorphism and the risk of developing endometriosis in an Italian population.

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Abstract

OBJECTIVES: Some controversy exists for the potential association of the plasminogen activator inhibitor-1 (PAI-1) gene polymorphism 4G/5G and susceptibility to endometriosis. To clarify this issue, we have examined the prevalence of this polymorphism in a case-control study in the Italian population. STUDY DESIGN: The PAI-1 4G/5G polymorphism was evaluated in n=368 reproductive year aged Caucasian women who underwent gynaecological laparoscopy for chronic pelvic pain, infertility, ovarian cysts and myomas. A second group of controls included n=329 normal subjects. RESULTS: The 697 women enrolled were divided as follows: the endometriosis group (n=204), the gynaecological control group (n=164) and the general population control group (n=329). No statistical significant differences emerged between endometriosis patients and gynaecological controls with regard to the allele frequencies and co-dominant and dominant models of genotype distribution. A borderline statistical difference was only observed for the recessive model of inheritance in which, contrary to previous findings, the PAI-1 4G/4G genotype seems to be less linked to the disease development. CONCLUSION: The findings reported herein do not support the previously reported data indicating a greater susceptibility to endometriosis in patients harbouring the PAI-1 4G/5G and 4G/4G genotypes and exclude a significant role of polymorphism in endometriosis development.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Genetic Predisposition to Disease Plasminogen Activator Inhibitor 1 Polymorphism, Genetic Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency Gene Frequency Genetic Predisposition to Disease Genetic Predisposition to Disease Genotype Genotype

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