[Therapy of endometriosis with dienogest]

G Köhler, Köhler G, Günter Köhler, Göretzlehner G, G Göretzlehner, G Görétzlehner, I Amon, Amon I
Zentralblatt für Gynäkologie · 1987 · vol. 109(12) , pp. 795–801 · PMID:3630463 · W2416048052
Non-randomised trial OA: closed CC0 ⤵ 12 in-corpus citations
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Dienogest, an orally active progestin, treated 57 women with endometriosis for 6 months, showing lesion disappearance in 66.7%, improvement in 80.4%, and symptomatic relief in 84%, with spotting and decreased libido as main side effects.

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Abstract

Dienogest (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4,9-dien-3-one, VEB Jenapharm, Jena, GDR), an orally active 19-nortestosterone derivative, was used firstly in the treatment of endometriosis. 57 patients (age 17-45 years) have been entered into the study. The diagnosis was confirmed by laparoscopy or laparotomy in 56 cases and in one case clinically. All patients have been treated with 2 mg dienogest per day in a progestin only regimen over a period of 6 month. The day after completing the course of dienogest therapy 51 patients underwent laparoscopy for control. On this basis endometriotic lesions had completely disappeared in 66.7%; in 80.4% a marked improvement was noted, but no effect was visible in 19.6% of the implants. Eighty-four per cent of the women reported symptomatic improvement. The efficacy of dienogest was correlated negative with the age of the treated women. The major side effects were spottings and decrease of libido. Blood pressure as well as mean body weight remained unaltered. No patient discontinued dienogest therapy due to side effects.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genital Neoplasms, Female Nandrolone Progesterone Congeners Adolescent Adolescent Adult Adult Endometriosis Endometriosis Female Female Follow-Up Studies Follow-Up Studies Genital Neoplasms, Female Genital Neoplasms, Female Humans Humans Middle Aged Middle Aged

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (12)

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