G Görétzlehner

Die Hormontherapie der Endometriose ist mit GnRH-Analoga, oralen hormonalen Kontrazeptiva (Mikropillen mit einer Ethinylestradiol-Dosis ≤30 µg und einem Gestagen) und Gestagenen möglich. Unmittelbar nach der histologischen Sicherung d…

Dienogest (17-alpha-Cyanomethyl-17b-hydroxy-4,9-estradien-3-on (DNG)) vereinigt die Vorzüge der 19-Nortestosteron-Derivate (Norgestagene) mit den typischen Eigenschaften der 17-alpha-Hydroxyprogesteron-Derivate. Dienogest ist der erste Repr…

Kupperman-index, weight, blood pressure, serum lipids, blood count, thrombocytes, fibrinogen, thrombine time, electrolytes, enzymes, serum proteins, bilirubine and other parameters were studied in 16 healthy post-menopausal women treated fo…

The effects of a new progestational compound, dienogest (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4,9-dien-3-one) on lipid metabolism have been studied in 84 otherwise healthy women with laparoscopically proven endometriosis. The women, a…

In a survey it is reported on the antiprogestins mifepristone (RU 486) and gestrinone (R 2323). Thanks to its high reversible affinity for progesterone receptor mifepristone stops progesterone activity at its target organs. Mifepristone als…

The pharmacology and the application in oral hormonal contraceptives of four new progestogens--gestodene, desogestrel, norgestimate, and dienogest--are described in a survey. Although derived from 19-norethisterone these progestogens exhibi…

Dienogest (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4,9-dien-3-one, VEB Jenapharm, Jena, GDR), an orally active 19-nortestosterone derivative, was used firstly in the treatment of endometriosis. 57 patients (age 17-45 years) have been ent…

The authors supply a survey about the aetiology varied classification systems and the hormontherapy of endometriosis. We have described the advantages and disadvantages of the therapy with progestagens, danazol, gestrinon and Gn RH agonists…