G Köhler

Einleitung: Das Gestagen Dienogest (DNG) stellt eine innovative wirkungsvolle hormonelle Behandlung der Endometriose dar. Ein wesentliches Ziel der Hormontherapie ist u.a. die Erzeugung eines hypoestrogenen Zustands durch Ausschalten des Re…

Eight otherwise healthy women aged 17 to 38 years with endometriosis were treated with 2 mg of the progestin dienogest daily for 24 weeks. Blood glucose and plasma insulin were measured prior to and during an intravenous glucose tolerance t…

In 130 sterile women undergoing first look laparoscopy we found in 86.9% patent tubes. In this group in 34.5% an endometriosis was discovered. All patients with closed tubes had no signs of endometriosis. In a second look laparoscopy we fou…

The effects of the progestational compound dienogest (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4,9-dien-3-one) on liver metabolism have been studied in 101 otherwise healthy women with endoscopically proven endometriosis. The women aged 1…

Endometriosis in an important disease especially for girls and young women. It often causes chronic complaints and infertility, requiring an early endoscopic diagnosis for their prophylaxis and therapy. The characteristics of endometriosis,…

The effects of a new progestational compound, dienogest (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4,9-dien-3-one) on lipid metabolism have been studied in 84 otherwise healthy women with laparoscopically proven endometriosis. The women, a…

In a survey it is reported on the antiprogestins mifepristone (RU 486) and gestrinone (R 2323). Thanks to its high reversible affinity for progesterone receptor mifepristone stops progesterone activity at its target organs. Mifepristone als…

Basal body temperature of 168 cycles have been measured in 20 infertile women (age 21-31 years) with endometriosis. There were 10.1% anovulatory cycles, and in 22.5% of the 151 biphasic cycles the hyperthermic phase lasted less than 11 days…

Dienogest (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4,9-dien-3-one, VEB Jenapharm, Jena, GDR), an orally active 19-nortestosterone derivative, was used firstly in the treatment of endometriosis. 57 patients (age 17-45 years) have been ent…

A case of endometriosis of the large intestine is reported in a 41 years old woman. The endometrioma involved the Bauhin-valve, the distal ileum and the right adnexa. The symptoms and signs were thought of a caecal carcinoma causing a mecha…