Carbohydrate Metabolism during Treatment of Endometriosis with the Progestin Dienogest *)

S Nikschick, G Köhler, Günter Köhler, E Männchen
Experimental and clinical endocrinology · 2009 · vol. 94(04/05) , pp. 211–214 · doi:10.1055/s-0029-1210899 · PMID:2689190 · W1995867157
article OA: closed CC0 ⤵ 9 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study investigated carbohydrate metabolism in women with endometriosis treated with dienogest, finding no significant changes in glucose levels but a slight, insignificant increase in insulin response over six months.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study enrolled eight otherwise healthy women aged 17–38 years with endometriosis and treated them with 2 mg dienogest daily for 24 weeks. Researchers measured fasting blood glucose and plasma insulin and performed intravenous glucose tolerance tests before and after 1, 3, and 6 months of therapy to assess carbohydrate metabolism, including insulin responses at multiple time points. They found no significant changes in fasting glucose or in glucose levels after glucose loading during treatment, with basal insulin unchanged and only a slight, statistically nonsignificant increase in insulin response at 10 and 20 minutes depending on therapy duration. The main limitation is the very small sample size and lack of statistically significant metabolic effects overall. This paper is centrally about endometriosis — it evaluates how dienogest treatment affects carbohydrate metabolism in women with endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Eight otherwise healthy women aged 17 to 38 years with endometriosis were treated with 2 mg of the progestin dienogest daily for 24 weeks. Blood glucose and plasma insulin were measured prior to and during an intravenous glucose tolerance test before and after 1, 3 and 6 months use of the oral progestin. There were no significant changes in fasting glucose and in glucose levels after the glucose load during the therapy though the fasting glucose levels tended to be higher under dienogest. The basal insulin values remained unchanged but the insulin response was slightly insignificantly increased after 10 and 20 minutes following glucose application depending on the duration of therapy. The data suggest that 2 mg dienogest administered daily has no or only a very slight influence on carbohydrate metabolism.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Blood Glucose Endometriosis Nandrolone Progesterone Congeners Adolescent Adult Blood Glucose Endometriosis Endometriosis Female Glucose Tolerance Test Humans Insulin Insulin Nandrolone Nandrolone Nandrolone Progesterone Congeners Progesterone Congeners

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (9)

Source provenance

europepmc
last seen: 2026-06-18T06:15:08.409253+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:09:10.744835+00:00
License: CC0 · commercial use OK