Carbohydrate Metabolism during Treatment of Endometriosis with the Progestin Dienogest *)

S Nikschick, Nikschick S, Günter Köhler, Köhler G, G Köhler, Männchen E, E Männchen
Experimental and clinical endocrinology · 2009 · vol. 94(04/05) , pp. 211–214 · doi:10.1055/s-0029-1210899 · PMID:2689190 · W1995867157
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study investigated carbohydrate metabolism in women with endometriosis treated with dienogest, finding no significant changes in glucose levels but a slight, insignificant increase in insulin response over six months.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This study enrolled eight otherwise healthy women aged 17–38 years with endometriosis and treated them with 2 mg dienogest daily for 24 weeks. Researchers measured fasting blood glucose and plasma insulin and performed intravenous glucose tolerance tests before and after 1, 3, and 6 months of therapy to assess carbohydrate metabolism, including insulin responses at multiple time points. They found no significant changes in fasting glucose or in glucose levels after glucose loading during treatment, with basal insulin unchanged and only a slight, statistically nonsignificant increase in insulin response at 10 and 20 minutes depending on therapy duration. The main limitation is the very small sample size and lack of statistically significant metabolic effects overall. This paper is centrally about endometriosis — it evaluates how dienogest treatment affects carbohydrate metabolism in women with endometriosis.

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Abstract

Eight otherwise healthy women aged 17 to 38 years with endometriosis were treated with 2 mg of the progestin dienogest daily for 24 weeks. Blood glucose and plasma insulin were measured prior to and during an intravenous glucose tolerance test before and after 1, 3 and 6 months use of the oral progestin. There were no significant changes in fasting glucose and in glucose levels after the glucose load during the therapy though the fasting glucose levels tended to be higher under dienogest. The basal insulin values remained unchanged but the insulin response was slightly insignificantly increased after 10 and 20 minutes following glucose application depending on the duration of therapy. The data suggest that 2 mg dienogest administered daily has no or only a very slight influence on carbohydrate metabolism.
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Subscribe to RSS DOI: 10.1055/s-0029-1210899 © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York Carbohydrate Metabolism during Treatment of Endometriosis with the Progestin Dienogest *) *) To Prof. Dr. sc. med. G. Dörner on occasion of his 60th birthday.Publication History 1988 Publication Date: 16 July 2009 (online) Summary Eight otherwise healthy women aged 17 to 38 years with endometriosis were treated with 2 mg of the progestin dienogest daily for 24 weeks. Blood glucose and plasma insulin were measured prior to and during an intravenous glucose tolerance test before and after 1, 3 and 6 months use of the oral progestin. There were no significant changes in fasting glucose and in glucose levels after the glucose load during the therapy though the fasting glucose levels tended to be higher under dienogest. The basal insulin values remained unchanged but the insulin response was slightly in-significantly increased after 10 and 20 minutes following glucose application depending on the duration of therapy. The data suggest that 2 mg dienogest administered daily has no or only a very slight influence on carbohydrate metabolism. Key words Gestagen - Dienogest - Carbohydrate metabolism

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Condition tags

endometriosis

MeSH descriptors

Blood Glucose Endometriosis Nandrolone Progesterone Congeners Adolescent Adult Blood Glucose Endometriosis Endometriosis Female Glucose Tolerance Test Humans Insulin Insulin Nandrolone Nandrolone Nandrolone Progesterone Congeners Progesterone Congeners

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