Histological confirmation of endometriosis in a 9-year-old girl suffering from unexplained cyclic pelvic pain since her eighth year of life
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Histological confirmation of endometriosis, involving stromal tissue and epithelial glands, was achieved in a 9-year-old premenarcheal girl experiencing cyclic pelvic pain since age eight.
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Abstract
OBJECTIVE: Endometriosis is considered an estrogen-dependent disease of women in their reproductive age and characterized by the occurrence of stromal cells and endometrial-like glands outside the uterine cavity.
PATIENT: A report of a 9-year-old premenarcheal girl who was transferred to the Endometriosis Research Center Berlin-Brandenburg Level III (Academic Teaching Hospital) because of cyclic pelvic pain since her 8th year of life.
INTERVENTIONS: History, examination, abdominal ultrasound, laboratory tests, laparoscopic resection of visible lesions. Paraffin-embedded histology (HE staining) and immunohistochemistry.
RESULTS: Endometriosis, defined as the presence of stromal tissue and epithelial glands, was confirmed both by HE staining and immunohistochemistry (CD10), respectively.
CONCLUSIONS: Young pre- or perimenarcheal girls with chronic/cyclic pelvic pain can have endometriosis, and thus the possibility of endometriosis should be included in the differential diagnosis.
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References (8)
- Adolescent endometriosis: diagnosis and treatment approaches via openalex
- Bone density in adolescents treated with a GnRH agonist and add-back therapy for endometriosis via openalex
- Endometriosis from thelarche to midteens: pathogenesis and prognosis, prevention and pedagogy via openalex
- Endometriosis in adolescence: a long-term follow-up fecundability assessment via openalex
- Endometriosis in an adolescent population: the Emory experience via openalex
- Endometriosis in premenarcheal girls who do not have an associated obstructive anomaly via openalex
- Management of adolescent chronic pelvic pain from endometriosis: a pain center perspective via openalex
- Prevalence of endometriosis in adolescent girls with chronic pelvic pain not responding to conventional therapy via openalex
Cited by (23)
- In Utero and Early-Life 2022
- A Revised Stem Cell Theory for the Pathogenesis of Endometriosis 2022
- Clinical Aspects of Adolescent Endometriosis 2021
- Laparoscopic Surgery in Adolescent Endometriosis 2020
- Reproductive Tract Anomalies in Adolescent Endometriosis 2020
- Reproductive Tract Anomalies in Adolescent Endometriosis 2020
- Neonatal Uterine Bleeding and Adolescent Endometriosis 2020
- Evolutionäre Aspekte in der Pathogenese und Pathophysiologie von Adenomyose und Endometriose 2019
- Unus pro omnibus, omnes pro uno: A novel, evidence-based, unifying theory for the pathogenesis of endometriosis 2017
- Cells with “Stemness”: Seeds for endometriosis? 2016
- Urinary Tract Endometriosis 2015
- Adenomyosis and endometriosis. Re-visiting their association and further insights into the mechanisms of auto-traumatisation. An MRI study 2014
- Endometriosis in association with Herlyn-Werner-Wunderlich syndrome 2014
- Endometriosis in association with Herlyn-Werner-Wunderlich 2014
- Endometriosis: a life cycle approach? 2013
- Embryologic origin of endometriosis: analysis of 101 human female fetuses 2011
- Peculiar aspects of endometriosis in adolescents 2010
- Common problems in pediatric and adolescent gynecology 2010
- The diagnosis and treatment of deep infiltrating endometriosis 2010
- Peculiar Aspects of Endometriosis in Adolescents 2010
- Pre-natal exposure of mice to bisphenol A elicits an endometriosis-like phenotype in female offspring 2010
- Expression of the epidermal growth factor receptor family in correlation to the estrogen receptor a expression in peritoneal and ovarian endometriosis 2009
- Expression of the Epidermal Growth Factor Receptor Family in Correlation to the Estrogen Receptor α Expression in Peritoneal and Ovarian Endometriosis 2009
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