Peritoneal and peripheral B-1-cell populations in patients with endometriosis

Fumihisa Chishima, F Chishima, S. Hayakawa, Satoshi Hayakawa, Hayakawa S, Y. Hirata, Hirata Y, N Nagai, Nobuhisa Nagai, Nagai N, Takashi Kanaeda, Kanaeda T, T Kanaeda, Tsubata K, Katsuo Tsubata, K. Tsubata, Kazuo Satoh, Satoh K, K Satoh
Journal of Obstetrics and Gynaecology Research · 2000 · vol. 26(2) , pp. 141–149 · doi:10.1111/j.1447-0756.2000.tb01298.x · PMID:10870308 · W1986478664
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Endometriosis patients showed increased peritoneal B-1 cells compared to controls, with peripheral B-1 cell levels correlating to antinuclear antibody production.

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Abstract

OBJECTIVE: The purpose of this study was to investigate the frequency of B-1 cells in the peritoneal cavity and peripheral blood of patients with endometriosis. MATERIALS AND METHODS: We examined 31 patients with endometriosis and 14 normal nonpregnant women. Peripheral blood cells and peritoneal exudate cells (PECs) were stained with FITC or PE-labeled anti-CD5/CD19 monoclonal antibodies. Immunofluorescence analysis was performed using a flow cytometer. The significance of differences between the patient and control groups was determined by the non-parametric Mann-Whitney test. RESULTS: There was no significant difference in the percentages of B-1 cells in the peripheral blood of women with and without endometriosis (median, 22.7%; range, 4.7-92.3% vs median, 20.05%; range, 11.1-12.6%, respectively). Endometriosis patients with antinuclear antibodies (ANAs) demonstrated significantly elevated B-1 cells compared to both endometriosis patients without ANAs and normal controls (p < 0.005 and p < 0.05, respectively). Endometriosis patients demonstrated significantly higher B-1 cell populations (B-1 cells/total B-cell ratio) in PECs than did non-endometriosis patients (p < 0.05). CONCLUSIONS: The peripheral B-1-cell population in patients with endometriosis is related to ANA production. B-1 cells might play important roles in the development of endometriosis through autoantibody production.

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Condition tags

endometriosis

MeSH descriptors

Blood Cells B-Lymphocyte Subsets Endometriosis Endometriosis Peritoneum Adult Adult Antibodies, Monoclonal Antibodies, Monoclonal Blood Cells Blood Cells B-Lymphocyte Subsets B-Lymphocyte Subsets Case-Control Studies Case-Control Studies CD5 Antigens CD5 Antigens Endometriosis Endometriosis Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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