Expression of vascular endothelial growth factor A isoforms is dysregulated in women with endometriosis

Kevin Danastas, Emily J. Miller, Miller EJ, Alison J Hey-Cunningham, Alison J. Hey‐Cunningham, Christopher R. Murphy, Laura A. Lindsay
Reproduction, fertility, and development · 2017 · vol. 30(4) , pp. 651–657 · doi:10.1071/rd17184 · PMID:29017687 · W2764060760
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This study found that vascular endothelial growth factor A isoforms, including newly identified VEGF111, are upregulated during menstruation in women with endometriosis compared to controls.

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Abstract

Angiogenesis is a critical step in the development of ectopic lesions during endometriosis. Although total vascular endothelial growth factor (VEGF) A is elevated in the peritoneal fluid of women with endometriosis, there are contradictory reports on how levels of total endometrial VEGFA are altered in this disease. Furthermore, limited research is available on different VEGFA isoforms in women with endometriosis. Thus, the aim of the present study was to analyse levels of various VEGFA isoforms in women with and without endometriosis at different stages of the menstrual cycle. Quantitative polymerase chain reaction analysis showed that total VEGFA was highest during menstruation in endometriosis compared with controls (P=0.0373). VEGF121 and VEGF189 were similarly highest during menstruation in endometriosis compared with controls (P=0.0165 and 0.0154 respectively). The present study is also the first to identify the natural expression of VEGF111 in human tissue, which is also highest during menstruation in endometriosis (P=0.0464). This discovery of the natural production of VEGF111 in human endometrium, as well as the upregulation of VEGFA isoforms during menstruation in endometriosis, may shed further light on the development and progression of the disease, and improve our understanding of the regulation of endometrial angiogenesis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Protein Isoforms Vascular Endothelial Growth Factor A Adolescent Adolescent Adult Adult Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Female Gene Expression Regulation Gene Expression Regulation Humans Humans Menstrual Cycle

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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