REASONS FOR ENDOMETRIOSIS-ASSOCIATED INFERTILITY

In: Reproductive Medicine · 2020 · pp. 43–48 · doi:10.37800/rm2020-1-17 · W3209561638
article OA: diamond CC0 ⤵ 3 in-corpus citations
AI-generated summary by claude@2026-06, 2026-06-11

This review identifies four key factors—tubal-peritoneal, ovarian, embryonic, and endometrial—contributing to infertility in endometriosis, highlighting the need for further research due to inconsistent scientific data.

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The paper discusses reasons and proposed mechanisms underlying infertility associated with endometriosis, focusing on what the literature calls four main factor categories: tubal-peritoneal, ovarian, embryonic, and endometrial. It frames these mechanisms within “versions and controversies” in the field and emphasizes that scientific evidence remains conflicting. A central limitation is that the article highlights uncertainty rather than resolving it, explicitly calling for further research to clarify the causal pathways. This paper is centrally about endometriosis — specifically reasons and mechanisms of endometriosis-associated infertility.

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Abstract

This article discusses the causes and mechanisms of the occurrence of infertility in endometriosis within the framework of versions and contraversions. The magnitude of the described problem is noted not only from a medical, but also from a socio-economic perspective. Four main factors of endometriosis-associated infertility were identified: tubal-peritoneal, ovarian, embryonic and endometrial. Given the inconsistency of scientific data, the need for further research is noted.
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Причины эндометриоз-ассоциированного бесплодия DOI: https://doi.org/10.37800/RM2020-1-17Ключевые слова: эндометриоз, бесплодиеАннотация В данной статье обсуждаются причины и механизмы возникновения бесплодия при эндометриозе в рамках версий и контраверсий. Выделено четыре основных фактора эндометриоз-ассоциированного бесплодия: трубно-перитонеальный, овариальный, эмбриональный и эндометриальный. Учитывая противоречивость научных данных, отмечена необходимость дальнейших исследований. Библиографические ссылки How old is endometriosis? Late 17th and 18th century description of the disease. Fertil Steril. 1999; 72: 10-4. Стрижаков А.Н. Современные аспекты этиологии и патогенеза различных форм генитального эндометриоза. Акушерство и гинекология. 1980; 10:13–17 [Strizhakov A.N. Sovremennye aspekty etiologii i patogeneza razlichnyh form genital'nogo endometrioza. Akusherstvo i ginekologiya. 1980; 10:13–17 (In Russian)]. Sun TT, Chen SK, Li XY et al. Fertility Outcomes After Laparoscopic Cystectomy in Infertile Patients with Stage III-IV Endometriosis: a Cohort with 6-10 years of Follow-up. Adv Ther. 2020. https://doi.org/10.6084/m9.figshare.11968545. Santulli P, Lamau MC, Marcellin L et al. Endometriosis-related infertility: ovarian endometrioma per se is not associated with presentation for infertility. Hum Reprod. 2016; 31(8): 1765-75. Ahn SH, Monsanto SP, Miller C et al. Pathophysiology and immune dysfunction in endometriosis. Biomed Res Int. 2015; 2015: 795976. Nanda A, K T, Banerjee P, Dutta M et al. Cytokines, Angiogenesis, and Extracellular Matrix Degradation are Augmented by Oxidative Stress in Endometriosis. Ann Lab Med. 2020; 40(5): 390-397. Адамян Л.В., Мартиросян Я.О., Асатурова А.В. Этиопатогенез эндометриоз-ассоциированного бесплодия (обзор литературы). Проблемы репродукции. 2018; 24(2): 28-33. [Adamyan L.V., Martirosyan YA.O., Asaturova A.V. Etiopatogenez endometrioz-associirovannogo besplodiya (obzor literatury). 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Endometriosis is not detrimental to embryo implantation in oocyte recipients. J Assist Reprod Genet 1997; 14: 152–6. Simon C, Gutierrez A, Vidal A, de los Santos MJ, Tarín JJ, Remohí J, et al. Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod 1994; 9: 725–9. Díaz I, Navarro J, Blasco L, Simon C, Pellicer A, Remohí J. Impact of stage III – IV endometriosis on recipients of sibling oocytes: matched case-control study. Fertil Steril 2000; 74: 31–4. Miravet-Valenciano J, Ruiz-Alonso M, Gomez E, Garcia-Velasco JA. Endometrial receptivity in eutopic endometrium in patients with endometriosis: it is not affected, and let me show you why. Fertil Steril. 2017; 108: 28–31. Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alama P, Pellicer A, et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril 2011; 95: 50–60. Garcia-Velasco JA, Fassbender A, Ruiz-Alonso M, Blesa D, Thomas DH, Simon C. Is endometrial receptivity transcriptomics affected in women with endometriosis? A pilot study. Reprod Biomed Online 2015; 31: 647–54 Craciunas L, Gallos I, Chu J et al. Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis. Hum Reprod Update. 2019; 25(2): 202-223. Дополнительные файлы Опубликован Как цитировать Выпуск Раздел Лицензия Публикуемые в этом журнале статьи размещены под лицензией CC BY-NC-ND 4.0 (Creative Commons Attribution — Non Commercial — No Derivatives 4.0 International), которая предусматривает только их некоммерческое использование. В соответствии с этой лицензией пользователи имеют право копировать и распространять материалы, охраняемые авторским правом, но им не разрешается изменять или использовать их в коммерческих целях. Полная информация о лицензировании доступна по адресу https://creativecommons.org/licenses/by-nc-nd/4.0/.

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