Л.М. Михалева

Endometriosis is a gynecological disorder characterized by the presence of tissue that is morphologically and functionally similar to the endometrium, but located outside the uterine cavity. The disease is chronic and prone to recurrence. A…

Introduction. Long-term chronic inflammation in the endometrium leads to sclerotic changes, disorders in the extracellular matrix and intercellular interactions, and, ultimately, to impaired formation of spiral arteries and hypoperfusion. T…

Endometriosis-associated fibrosis is a complex phenomenon, and the underlying mechanisms are still not fully understood. Fibrosis is invariably present in all forms of the disease and contributes to the classic endometriosis-associated symp…

Chronic endometritis is widespread among women of reproductive age, it can be the cause of menstrual disorders, abnormal uterine bleeding and, finally, infertility of uterine genesis. The issue of impaired immune status of the glandular-str…

To date, one of the most common endometriosis types is uterine endometriosis (adenomyosis). Persistent adenomyosis in older age is followed by worsening of complaints associated with a high frequency of chronic pelvic pain syndrome, menorrh…

Abnormal uterine bleeding (AUB), common in a cohort of women in the reproductive period, is undoubtedly an extremely important factor reducing quality of life. Persistent endometrial inflammation is a pathogenetic link associated with endom…

Endometriosis is a gynecological disease that affects up to 10% of women of reproductive age and is characterized by pronounced heterogeneity of clinical manifestations and pathogenetic mechanisms. Despite significant advances in diagnostic…

The endometrium is one of the most dynamic tissues that constantly undergoes changes during the menstrual cycle in women of the reproductive period. All these processes take place mainly under the influence of steroid hormones that are prod…

Introduction Endometriosis ranks second place in the structure of infertility. The development of endometrial dysfunction is one of the infertility factors, which affects the degree of decrease in the receptive abilities of endometrium and …

Endometriosis has been studied for more than 100 years, but to date, none of the proposed therapeutic strategies has provided a complete cure or avoided recurrence of the disease. This review considers current treatment options for endometr…

This review is devoted to endometriosis-associated immune cells and immune molecules, analysis of various databases, new insights, theories, biomarkers, reviews of research in this area. To date, many attempts have been made to establish a …

Background. Infertility tends to become one more modern pandemic. According to some estimates, the percentage of infertile couples varies between 10–25% (48–180 million). Such couples face adverse effects on their physical and mental health…

The mechanisms of ovarian endometrioid cyst formation, or cystic ovarian endometriosis, still remain to be elucidated. To address this issue, we analyzed the involvement of mast cell (MC) tryptase and carboxypeptidase A3 (CPA3) in the devel…

Objective. Objective of this review is the systematic analysis and summarization the scientifc data available in the current literature on the predictive approach to the management of women with endometrial hyperplasia without atypia. Mater…

BACKGROUND: In patients of reproductive age with endometrial hyperplasia without atypia, hormonal treatment, and prognosis of response remain relevant issues. AIM: To increase the effectiveness of hormonal therapy for endometrial hyperplasi…

BACKGROUND: Currently, the incidence of benign ovarian tumors has increased, and numerous studies have reported its negative effect on womens reproductive health. In modern literature, approximately 30% of patients with ovarian neoplasms ha…

Violation of the receptivity of the endometrium in adenomyosis can be supported either by pathological processes in the structure of the endometrium, such as an unexpected increase in vascularization and thickness of the endometrial stroma …

Relevance. The identification of the relationship between adenomyosis and infertility, as well as the possible overcoming of the consequences, is one of the main tasks of reproduction. Despite the fact that adenomyosis is more often detecte…

Aim. To identify risk factors for in vitro fertilization (IVF) failures in women with adenomyosis-associated infertility. Materials and methods. The study included 83 patients of reproductive age with adenomyosis. Women were divided into t…

Among all endometriosis lesions of female reproductive organs, ovarian endometrioma is the most discussed nosology. Since 2014, ovarian endometrioid cysts have been classified as benign tumors (WHO Classification of Tumours of Female Reprod…