Modeling endometriosis in mice and pharmacological activity of the drug Endoferin

A. V. Ilyichev, M V Belopolskaya, Vsevolod V. Pavshintsev, David A. Areshidze, A. A. Bustios-Guryanova, Maxim L. Lovat, Л.М. Михалева
In: Bulletin of Experimental Biology and Medicine · 2025 · vol. 180(8) , pp. 203–207 · doi:10.47056/0365-9615-2025-180-8-203-207 · W4413994991
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This paper models endometriosis in mice and evaluates the pharmacological activity of the drug Endoferin within this model.

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This study developed a murine model of endometriosis by autotransplanting uterine horn fragments onto the intestinal mesentery to evaluate the pharmacological activity of the drug Endoferin. Researchers compared three experimental paradigms, including protocols with and without exogenous estradiol administration, and observed well-demarcated endometriomas at all implantation sites. The results indicated that Endoferin was most effective in a short-term, hormone-free protocol, whereas the introduction of estradiol hindered the drug's therapeutic manifestation. This paper is centrally about endometriosis — specifically utilizing a mouse model to assess the efficacy of a new therapeutic agent against the disease.

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Содержание и архив номеров 2025 г., Том 180, № 8 АВГУСТ Фармакология и токсикология Моделирование эндометриоза у мышей и фармакологическая активность препарата "Эндоферин" Исследовали модель эндометриоза, позволяющую оценить фармакологическую активность лекарственных препаратов. Моделирование эндометриоза осуществляли путём аутотрансплантации участка рога матки на брыжейку кишечника мыши в трёх вариантах: с введением эстрадиола; в сокращённом по времени эксперименте без введения эстрадиола; в продолжительном по времени эксперименте без введения эстрадиола и с отсроченным введением исследуемого препарата. В условиях модели у всех мышей в месте имплантации хорошо визуализировались образования округлой формы — эндометриомы. Эндоферин эффективнее проявлял свою активность в сокращённом варианте моделирования эндометриоза. Введение экзогенного эстрадиола мешало проявлению фармакологической активности препарата. В результате разработан быстрый способ оценки терапевтической эффективности лекарственных препаратов in vivo. Ключевые слова: эндометриоз; мыши; эндоферин; эстрадиол Адрес для корреспонденции: [email protected] Ильичёв А.В. DOI: 10.47056/0365-9615-2025-180-8-203-207 EDN: VCTERO Modeling endometriosis in mice and pharmacological activity of the drug Endoferin A murine model of endometriosis was employed to evaluate the pharmacological efficacy of therapeutic compounds. Endometriosis was induced by autotransplantation of uterine horn fragments onto the intestinal mesentery in three experimental paradigms: with subcutaneous administration of estradiol; a short-term protocol without estradiol; and a prolonged protocol without estradiol, with delayed administration of the test compound. In all animals, well-demarcated, rounded endometriotic lesions (endometriomas) were consistently observed at the implantation sites. Endoferin demonstrated its highest efficacy under the short-term, hormone-free protocol. The administration of exogenous estradiol interfered with the manifestation of the drug's pharmacological activity. As a result, a rapid in vivo method for assessing the therapeutic efficacy of candidate drugs was developed. Key Words: endometriosis; mice; Endoferin; estradiol

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