Эндометриоидные гетеротопии с низкой пролиферативной активностью, наличием сосудов синусоидного типа, железы с кистозно расширенным просветом, уплощенным кубическим эпителием; окраска гематоксилином и эозином, х250 (А) Показатель маркера Ki-67 в образцах с низкой клеточной активностью в строме -5-7% (Б), в железах 1-3% (В). Эндометриоидные гетеротопии с умеренной пролиферативной активностью: сосудистые почки, железы трубчатой формы с двухрядным эпителием, окраска гематоксилином и эозином, х250 (Г, Д); показатель маркера Ki-67 со средней клеточной активностью в железах 42% (Е), в «горячих точках» - до 80% (Ж). Эндометриоидные гетеротопии с высокой пролиферативной активностью: эпителий желез многорядный, строма слабо развита, окраска гематоксилином и эозином, х250 (З); показатель маркера Кі-67 с высокой клеточной активностью в клетках желез эндометрия 90% (И), в строме эндометрия до 35% (К)
Pathological analysis of diffuse adenomyosis in patients with ovarian follicular cysts reveals endometrioid heterotopias characterized by low, moderate, or high proliferative activity as indicated by Ki-67 staining patterns.
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This study examines the pathological and morphogenetic features of proliferating diffuse adenomyosis in patients with ovarian follicular cysts. The authors analyzed endometrioid heterotopies categorized by low, moderate, and high proliferative activity using hematoxylin and eosin staining alongside Ki-67 markers to quantify cellular proliferation rates. Results demonstrated distinct histological patterns and significant variations in Ki-67 indices across different activity levels, ranging from minimal stromal activity in low-proliferation cases to near-maximal epithelial proliferation in high-activity lesions. Relevance to endometriosis: explicitly discusses endometrioid heterotopies and adenomyosis as central components of the research pathology.
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