Endometriosis. New therapeutic targets

Olga I. Patsap, A.V. Babkina, M.B. Khabarova, Anastasiia A. Buyanova, S.A. Mikhalev, D. A. Atyakshin, A.I. Davydov, Л.М. Михалева, Michael Ignatyuk, Artem Volodkin
In: Voprosy ginekologii, akušerstva i perinatologii · 2023 · vol. 22(4) , pp. 80–91 · doi:10.20953/1726-1678-2023-4-80-91 · W4391565062
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This review examines current endometriosis treatments based on pathogenesis, discusses their pros and cons, and explores new therapeutic targets due to the lack of a definitive cure or method to prevent recurrence.

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This review examines the current therapeutic landscape for endometriosis, highlighting that no existing strategy offers a complete cure or prevents recurrence. The authors evaluate treatment options based on pathogenetic principles while noting significant gaps in defining optimal treatment windows and the role of pharmacotherapy as an adjuvant to surgery. They argue that new therapeutic targets must be identified by integrating recent data on the disease's complex pathogenesis. This paper is centrally about endometriosis — specifically reviewing new therapeutic targets derived from updated understanding of its pathogenesis.

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Abstract

Endometriosis has been studied for more than 100 years, but to date, none of the proposed therapeutic strategies has provided a complete cure or avoided recurrence of the disease. This review considers current treatment options for endometriosis according to the pathogenetic principle, discusses the advantages and disadvantages of each of them. It remains difficult to define a window of opportunity for the treatment of endometriosis. There are currently no recognized treatment methods that prevent the development of this pathology; there is no evidence for the role of pharmacotherapy as an adjuvant to surgery, and it remains unclear how to treat disease recurrence. Therefore, new therapeutic targets in the treatment of this complex pathology are considered from the perspective of recent data on the pathogenesis of endometriosis. Key words: endometriosis, pathogenesis, endometriosis treatment, surgical treatment
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Endometriosis. New therapeutic targets Endometriosis has been studied for more than 100 years, but to date, none of the proposed therapeutic strategies has provided a complete cure or avoided recurrence of the disease. This review considers current treatment options for endometriosis according to the pathogenetic principle, discusses the advantages and disadvantages of each of them. It remains difficult to define a window of opportunity for the treatment of endometriosis. There are currently no recognized treatment methods that prevent the development of this pathology; there is no evidence for the role of pharmacotherapy as an adjuvant to surgery, and it remains unclear how to treat disease recurrence. Therefore, new therapeutic targets in the treatment of this complex pathology are considered from the perspective of recent data on the pathogenesis of endometriosis. Key words: endometriosis, pathogenesis, endometriosis treatment, surgical treatment For citation: Patsap O.I., Babkina A.V., Khabarova M.B., Buyanova A.A., Mikhalev S.A., Atyakshin D.A., Davydov A.I., Mikhaleva L.M., Ignatyuk M.A., Volodkin A.V. Endometriosis. New therapeutic targets. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2023; 22(4): 80–91. (In Russian). DOI: 10.20953/1726-1678-2023-4-80-91 Open access

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