S.A. Mikhalev

Multimorbidity is a key global trend across healthcare fields, including gynecology. It is strongly associated with an overall poorer health status. Statistics indicate that in the 21st century most women experience at least one gynecologic…

Currently, there is an increase in benign ovarian tumors, which negatively affect the fertility potential of women and cause infertility. It is relevant to study the morpho-functional state of the endometrial pattern in women with benign ov…

A trend toward comorbid conditions is seen in around 50% of gynecological patients, with a significant contribution made by endometriosis as a common and incurable gynecological condition. Over the last decades, the global burdens of differ…

Introduction. Long-term chronic inflammation in the endometrium leads to sclerotic changes, disorders in the extracellular matrix and intercellular interactions, and, ultimately, to impaired formation of spiral arteries and hypoperfusion. T…

Endometriosis-associated fibrosis is a complex phenomenon, and the underlying mechanisms are still not fully understood. Fibrosis is invariably present in all forms of the disease and contributes to the classic endometriosis-associated symp…

Chronic endometritis is widespread among women of reproductive age, it can be the cause of menstrual disorders, abnormal uterine bleeding and, finally, infertility of uterine genesis. The issue of impaired immune status of the glandular-str…

Abnormal uterine bleeding (AUB), common in a cohort of women in the reproductive period, is undoubtedly an extremely important factor reducing quality of life. Persistent endometrial inflammation is a pathogenetic link associated with endom…

Introduction Endometriosis ranks second place in the structure of infertility. The development of endometrial dysfunction is one of the infertility factors, which affects the degree of decrease in the receptive abilities of endometrium and …

Endometriosis has been studied for more than 100 years, but to date, none of the proposed therapeutic strategies has provided a complete cure or avoided recurrence of the disease. This review considers current treatment options for endometr…

This review is devoted to endometriosis-associated immune cells and immune molecules, analysis of various databases, new insights, theories, biomarkers, reviews of research in this area. To date, many attempts have been made to establish a …

BACKGROUND: Currently, the incidence of benign ovarian tumors has increased, and numerous studies have reported its negative effect on womens reproductive health. In modern literature, approximately 30% of patients with ovarian neoplasms ha…

OBJECTIVE: To review the mechanisms of endometriosis development, including those related to epigenetic mutations, cellular dysregulation, inflammatory processes, and oxidative stress. METHODS: A systematic literature review regarding curre…

ВВЕДЕНИЕ На сегодняшний день бесплодие отмечено почти у 10% пар репродуктивного возраста во всем мире. В настоящей статье рассмотрена одна из причин возникновения бесплодия, обусловленного эндометриозом яичников, — морфофункциональная непол…