Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis

Jing Zhang, Zhang J, Lihui Wang, Wang L, Chunyan Li, Li C, Zhang H, Hui Zhang, Li R, Rui Li, Mingjiang Li, Li M
Systems biology in reproductive medicine · 2021 · vol. 68(2) , pp. 121–128 · doi:10.1080/19396368.2021.2013577 · PMID:34962452 · W4200627341
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Letrozole treatment in a rat endometriosis model increased the expression of integrin αvβ3 and HOXA10, thereby improving endometrial receptivity.

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Abstract

Endometriosis is a common estrogen-dependent chronic inflammatory disease that leads to infertility in women of reproductive age. Perhaps infertility reflects the reduced expression of integrin αvβ3 and HOXA10 in endometriosis. Previous studies have shown that administration of letrozole, a non-steroidal aromatase inhibitor for cancer treatment, increased the clinical pregnancy rate in women with endometriosis, but the mechanisms remain to be determined. In this communication, a rat model of endometriosis was established. Animals were treated with letrozole at 2ug/kg of body weight, intragastric administration for 15 consecutive days. Letrozole increased the expression of αvβ3 and HOXA10 in the endometriosis model and endometrial receptivity.Abbreviations: WOI: window of implantation; RGD: Arg-Gly-Asp; HOX: homeobox; E2: estradiol; SPF: specific pathogen-free.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Infertility, Female Infertility, Female Infertility, Female Animals Animals Embryo Implantation Embryo Implantation Endometrium Endometrium Endometrium Female Female Homeobox A10 Proteins Homeobox A10 Proteins Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (8)

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