Oral estroprogestins after laparoscopic surgery to excise endometriomas: continuous or cyclic administration? Results of a multicenter randomized study

Ludovico Muzii, Maneschi F, Francesco Maneschi, Riccardo Marana, Marana R, Maria Grazia Porpora, Errico Zupi, Filippo Bellati, Roberto Angioli, Pierluigi Benedetti Panici, Benedetti Panici P
Journal of Minimally Invasive Gynecology · 2011 · vol. 18(2) , pp. 173–178 · doi:10.1016/j.jmig.2010.11.004 · PMID:21262590 · W2171612524
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This randomized study investigated whether continuous or cyclic administration of oral estroprogestins is more effective after laparoscopic surgery for endometrioma excision.

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Abstract

STUDY OBJECTIVE: To evaluate continuous (CON) compared with cyclic (CYC) administration of combined oral estroprogestins for 6 months after laparoscopic excision of ovarian endometriomas associated with pain. DESIGN: Multicenter, prospective, randomized trial (Canadian Task Force classification I). SETTING: Tertiary care university hospitals. PATIENTS: Fifty-seven women aged 18 to 40 years with ovarian endometriomas associated with moderate to severe pelvic pain who underwent laparoscopic excision of the disease. INTERVENTIONS: Patients were randomized to receive postoperative estroprogestins for 6 months, administered as either a CON or CYC regimen. MEASUREMENTS AND MAIN RESULTS: At 3, 6, 12, and 24 months postoperatively, patients were evaluated for recurrence of endometriomas (defined as cysts >3 cm in greatest diameter) using ultrasonography, for recurrence of pain using a visual analog scale, and for patient satisfaction. After a minimum follow-up of 12 months (mean, 22 months), at intent-to-treat analysis, no endometrioma recurrence was observed in the CON group, whereas there was recurrence in 1 patient (4%) in the CYC group. Pain recurred in 5 and 9 patients, respectively (17% vs 32%; p = .23). Compared with pretreatment values, pain scores improved in both groups, with no significant difference between the 2 groups. Most patients in both groups were either satisfied or very satisfied, with no significant difference between treatment groups. However, compared with the CYC group, significantly more patients in the CON group experienced moderate to severe adverse effects, and therapy was discontinued (41% vs 14%; p = .03). CONCLUSIONS: Although both regimens were equally effective insofar as postoperative pain and recurrence of endometrioma, when compared with the CYC regimen, the CON regimen seems to be associated with significantly more adverse effects and discontinuation rates.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ethinyl Estradiol Norpregnenes Ovarian Diseases Pain Adolescent Adolescent Adult Adult Drug Administration Schedule Drug Administration Schedule Drug Combinations Drug Combinations Endometriosis Endometriosis Endometriosis Endometriosis Ethinyl Estradiol Ethinyl Estradiol Ethinyl Estradiol

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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