Reply to: Continuous versus cyclic oral contraceptives for endometriosis: any conclusive evidence?

Konstantinos A Zorbas, Konstantinos P Economopoulos, Nikolaos Vlahos, Nikos F Vlahos
Archives of gynecology and obstetrics · 2015 · vol. 292(3) , pp. 479–480 · doi:10.1007/s00404-015-3780-4 · PMID:26048262 · W3141374749
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-13 ⓘ

This reply discusses the evidence regarding continuous versus cyclic oral contraceptives for endometriosis treatment, referencing previous studies and systematic reviews.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper is a brief reply by Zorbas and colleagues responding to a comment about the article “Continuous versus cyclic oral contraceptives for endometriosis: any conclusive evidence.” It addresses the exchange at the level of the evidence discussion and maintains that, based on the literature considered in the earlier review topic, definitive conclusions are limited. The main caveat is that it is not a new clinical study but a commentary reply tied to previously published systematic-review material. Relevance to endometriosis: the paper is directly about endometriosis treatments and discusses the evidence base comparing continuous versus cyclic oral contraceptive regimens.

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References Muzii L, di Tucci C, Achilli C, Benedetti Panici P (2015) Continuous versus cyclic oral contraceptives for endometriosis: any conclusive evidence? Arch Gynecol Obstet. doi:10.1007/s00404-015-3776-0 Zorbas KA, Economopoulos KP, Vlahos NF (2015) Continuous versus cyclic oral contraceptives for the treatment of endometriosis: a systematic review. Arch Gynecol Obstet 292(1):37–43. doi:10.1007/s00404-015-3641-1 Muzii L, Maneschi F, Marana R, Porpora MG, Zupi E, Bellati F et al (2011) Oral estroprogestins after laparoscopic surgery to excise endometriomas: continuous or cyclic administration? Results of a multicenter randomized study. J Minim Invasive Gynecol 18:173–178 Vercellini P, Frontino G, De Giorgi O, Pietropaolo G, Pasin R, Crosignani PG (2003) Continuous use of an oral contraceptive for endometriosis-associated recurrent dysmenorrhea that does not respond to a cyclic pill regimen. Fertil Steril 80:560–563 Seracchioli R, Mabrouk M, Frasca C, Manuzzi L, Montanari G, Keramyda A et al (2010) Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: a randomized controlled trial. Fertil Steril 93:52–56 Seracchioli R, Mabrouk M, Frasca C, Manuzzi L, Savelli L, Venturoli S (2010) Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial. Fertil Steril 94:464–471 Conflict of interest None. Author information Authors and Affiliations Corresponding author Additional information This reply refers to the comment available at doi:10.1007/s00404-015-3776-0. Rights and permissions About this article Cite this article Zorbas, K.A., Economopoulos, K.P. & Vlahos, N.F. Reply to: Continuous versus cyclic oral contraceptives for endometriosis: any conclusive evidence?. Arch Gynecol Obstet 292, 479–480 (2015). https://doi.org/10.1007/s00404-015-3780-4 Published: Issue date: DOI: https://doi.org/10.1007/s00404-015-3780-4

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Condition tags

endometriosis

MeSH descriptors

Contraceptives, Oral Endometriosis Contraceptives, Oral Endometriosis Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (6)

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