Oral Estroprogestins after Laparoscopic Surgery to Excise Endometriomas: Continuous or Cyclic Administration? Results of a Multicenter Randomized Study

Ludovico Muzii, Maneschi F, Francesco Maneschi, Riccardo Marana, Marana R, Maria Grazia Porpora, Errico Zupi, Filippo Bellati, Roberto Angioli, Pierluigi Benedetti Panici, Benedetti Panici P
Journal of Minimally Invasive Gynecology · 2011 · vol. 18(2) , pp. 173–178 · doi:10.1016/j.jmig.2010.11.004 · PMID:21262590 · W2171612524
article OA: closed CC0 ⤵ 32 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This randomized study investigated whether continuous or cyclic administration of oral estroprogestins is more effective after laparoscopic surgery for endometrioma excision.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Study objectiveTo evaluate continuous (CON) compared with cyclic (CYC) administration of combined oral estroprogestins for 6 months after laparoscopic excision of ovarian endometriomas associated with pain.DesignMulticenter, prospective, randomized trial (Canadian Task Force classification I).SettingTertiary care university hospitals.PatientsFifty-seven women aged 18 to 40 years with ovarian endometriomas associated with moderate to severe pelvic pain who underwent laparoscopic excision of the disease.InterventionsPatients were randomized to receive postoperative estroprogestins for 6 months, administered as either a CON or CYC regimen.Measurements and main resultsAt 3, 6, 12, and 24 months postoperatively, patients were evaluated for recurrence of endometriomas (defined as cysts >3 cm in greatest diameter) using ultrasonography, for recurrence of pain using a visual analog scale, and for patient satisfaction. After a minimum follow-up of 12 months (mean, 22 months), at intent-to-treat analysis, no endometrioma recurrence was observed in the CON group, whereas there was recurrence in 1 patient (4%) in the CYC group. Pain recurred in 5 and 9 patients, respectively (17% vs 32%; p = .23). Compared with pretreatment values, pain scores improved in both groups, with no significant difference between the 2 groups. Most patients in both groups were either satisfied or very satisfied, with no significant difference between treatment groups. However, compared with the CYC group, significantly more patients in the CON group experienced moderate to severe adverse effects, and therapy was discontinued (41% vs 14%; p = .03).ConclusionsAlthough both regimens were equally effective insofar as postoperative pain and recurrence of endometrioma, when compared with the CYC regimen, the CON regimen seems to be associated with significantly more adverse effects and discontinuation rates.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Ethinyl Estradiol Norpregnenes Ovarian Diseases Pain Adolescent Adult Drug Administration Schedule Drug Combinations Endometriosis Endometriosis Endometriosis Ethinyl Estradiol Ethinyl Estradiol Female Gynecologic Surgical Procedures Humans Laparoscopy Norpregnenes Norpregnenes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (18)

Cited by (32)

Source provenance

europepmc
last seen: 2026-08-02T06:10:09.037253+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:16:54.825375+00:00
License: CC0 · commercial use OK