Continuous versus cyclic oral contraceptives for endometriosis: any conclusive evidence?

Ludovico Muzii, Chiara Di Tucci, Achilli C, Chiara Achilli, Pierluigi Benedetti Panici
Archives of gynecology and obstetrics · 2015 · vol. 292(3) , pp. 477–478 · doi:10.1007/s00404-015-3776-0 · PMID:26041327 · W1627217017
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⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-06-24 ⓘ

This paper discusses the existing systematic reviews and randomized controlled trials regarding the use of continuous versus cyclic oral contraceptives for endometriosis treatment and recurrence.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This paper is titled as a comment associated with an article and author reply concerning whether there is conclusive evidence on continuous versus cyclic oral contraceptives for endometriosis, referencing a systematic review and randomized trials. It discusses the evidence landscape rather than presenting new participant data, pointing to long-term randomized comparisons of cyclic versus continuous oral contraceptive regimens after endometrioma surgery and regarding recurrence and postoperative pain. A key limitation acknowledged by the nature of a comment/response format is that it does not provide definitive new results itself, relying on the underlying studies and their interpretation. This paper is centrally about endometriosis—specifically, it evaluates whether existing evidence is conclusive regarding continuous versus cyclic oral contraceptive strategies.

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References Zorbas KA, Economopoulos KP, Vlahos NF (2015) Continuous versus cyclic oral contraceptives for the treatment of endometriosis: a systematic review. Arch Gynecol Obstet 292(1):37–43. doi:10.1007/s00404-015-3641-1 Seracchioli R, Mabrouk M, Frascà C, Manuzzi L, Montanari G, Keramyda A, Venturoli S (2010) Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: a randomized controlled trial. Fertil Steril 93(1):52–56 Seracchioli R, Mabrouk M, Frascà C, Manuzzi L, Savelli L, Venturoli S (2010) Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial. Fertil Steril 94(2):464–471 Muzii L, Maneschi F, Marana R, Porpora MG, Zupi E, Bellati F, Angioli R, Benedetti Panici P (2011) Oral estroprogestins after laparoscopic surgery to excise endometriomas: continuous or cyclic administration? Results of a multicenter randomized study. J Minim Invasive Gynecol 18(2):173–178 Conflict of interest The authors declare no conflict of interest. Author information Authors and Affiliations Corresponding author Additional information This comment refers to the article available at doi:10.1007/s00404-015-3641-1 and an author’s reply to this comment is available at doi:10.1007/s00404-015-3780-4. Rights and permissions About this article Cite this article Muzii, L., di Tucci, C., Achilli, C. et al. Continuous versus cyclic oral contraceptives for endometriosis: any conclusive evidence?. Arch Gynecol Obstet 292, 477–478 (2015). https://doi.org/10.1007/s00404-015-3776-0 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00404-015-3776-0

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Condition tags

endometriosis

MeSH descriptors

Contraceptives, Oral Endometriosis Contraceptives, Oral Contraceptives, Oral Endometriosis Endometriosis Female Female Humans Humans

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Cited by (4)

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License: CC0 · commercial use OK