Expression of stem cell-related genes in the endometrium and endometriotic lesions: a pilot study

Fettback PB, P.B. Fettback, Paula B T Fettback, Ricardo Pereira, Pereira RM, Ricardo M. A. Pereira, André Monteiro da Rocha, André M Rocha, Rocha AM, Soares JM Jr, José Maria Soares, Smith GD, Gary D. Smith, Edmund C Baracat, Baracat EC, Edmund Chada Baracat, Serafini Pc, P. Serafini, Paulo C Serafini
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2015 · vol. 32(1) , pp. 82–86 · doi:10.3109/09513590.2015.1092135 · PMID:26426155 · W1833983509
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This study compared stem cell-related gene expression in endometrial and endometriotic tissues, finding that 40 of 84 genes were differentially expressed in superficial and deep endometriosis compared to normal endometrium.

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Abstract

OBJECTIVE: To compare the expression of stem cell-related genes in the endometrium (END), superficial endometriosis (SE), and deep infiltrating endometriosis (DIE). STUDY DESIGN: We performed a prospective pilot study of six women suffering from SE and DIE who gave consent for laparoscopy surgery, endometrial biopsies, and participation in this study. Quantitative RT-PCR analysis of 84 stem cell-related genes was performed in 18 biopsy samples. RESULTS: A total of 40 of 84 genes were expressed in SE and DIE, but were different from END as follows. Seven genes were over-expressed in SE and 33 genes were under-expressed in DIE compared with END. Two genes were only over-expressed in SE and three genes were only over-expressed in DIE. Six under-expressed genes were exclusively located in SE and one was only located in DIE. The remaining 31 genes were not different among the groups. There was no significant difference in gene expression between SE and DIE samples. CONCLUSION: Tissue of DIE and SE appears to have similar stem cell-related genes. Nevertheless, there are differences in gene expression between SE and DIE.

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Endometriosis Endometrium RNA, Messenger Stem Cells Adult Adult Biopsy Biopsy Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Female Gene Expression Gene Expression Humans Humans

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