An overview of treatments for endometriosis

Julie Brown, Cindy Farquhar, Cynthia Farquhar, Farquhar C
JAMA · 2015 · vol. 313(3) , pp. 296 · doi:10.1001/jama.2014.17119 · PMID:25603001 · W2048674580
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Levonorgestrel-releasing IUDs, GnRH analogues, and laparoscopic ablation/excision alleviate endometriosis pain and increase pregnancy rates, but GnRH analogues, danazol, and depot progestagens carry higher risks of adverse events.

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Abstract

CLINICAL QUESTION: What treatments are associated with improved outcomes for women with endometriosis? BOTTOM LINE: The levonorgestrel-releasing intrauterine system (LNG-IUD), gonadotropin-releasing hormone analogues (GnRHa; nafarelin, leuprolide, buserelin, goserelin, triptorelin), laparoscopic ablation, and excision are associated with relief of pain due to endometriosis. Gonadotropin-releasing hormone analogues and laparoscopic ablation or excision are associated with increased clinical pregnancy rates in women with endometriosis. Gonadotropin-releasing hormone analogues, danazol, and depot progestagens are associated with a higher incidence of adverse events.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Endometriosis Gonadotropin-Releasing Hormone Levonorgestrel Endometriosis Endometriosis Female Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Humans Levonorgestrel Levonorgestrel Pelvic Pain Pelvic Pain Pelvic Pain Pelvic Pain

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (5)

Cited by (50)

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