The pathogenesis and aetiology of endometriosis

Despite being one of the most frequently encountered gynaecological diseases requiring surgery and medical treatment, the pathophysiology of endometriosis remains controversial. Since the turn of the century, there has been substantial interest in this fascinating disease, but relatively little objective scientific data are available concerning its cause, natural history and, particularly, its relationship to infertility. It has been estimated that approximately 10–15% of all premenopausal women have endometriosis, albeit not all the women are symptomatic1. As a consequence, this represents a major clinical problem and consumes a significant proportion of the health care expenditures for gynaecological care. Until a better understanding of the pathophysiology of this disease is reached, effective therapy and, hopefully, prevention will elude us. This article attempts to review the relevant literature regarding the pathophysiology of endometriosis in an effort to identify those areas that may prove profitable for future research endeavors. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

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