Myometrial prostaglandins during the human menstrual cycle

R Vijayakumar, William A. W. Walters
In: American Journal of Obstetrics and Gynecology · 1981 · vol. 141(3) , pp. 313–318 · doi:10.1016/s0002-9378(16)32639-4 · PMID:7306368 · W168519028
article OA: closed CC0 ⤵ 8 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study quantified myometrial prostaglandin levels across the human menstrual cycle, revealing specific patterns of production in different phases.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Prostaglandins E and F (PGE, PGF) and their 13,14-dihydro-15-keto metabolites were measured by radioimmunoassay in myometrium obtained from 27 women during abdominal hysterectomy for benign gynecologic conditions at defined stages of the menstrual cycle. Excepting the late secretory phase, when myometrial PGF concentrations were highest, the myometrial PGE concentration exceeded that of PGF throughout most of the menstrual cycle, especially during the late proliferative phase. The prostaglandin metabolites in myometrium did not fluctuate during the cycle, but their respective ratios with the parent prostaglandins showed changes indicative of increased biosynthesis and/or reduced catabolism of PGF and reduced biosynthesis and/or increased catabolism of PGE during the late secretory phase. The results suggest that PGE is involved in the mechanism of increased myometrial activity in the periovulatory period and that PGF may be important in the initiation of menstruation.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (8)

SciLite annotations

chemicals 5
prostaglandin prostaglandins e keto mycolate prostaglandin prostaglandin
organisms 1
human

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
scilite
last seen: 2026-05-18T04:57:49.680383+00:00
unpaywall
last seen: 2026-08-07T06:39:35.550527+00:00
License: CC0 · commercial use OK