Cutaneous endometriosis in the umbilical region: The usefulness of CD10 in identifying the interstitium of ectopic endometriosis

Fukuda H, Hidetsugu Fukuda, Hideki Mukai, Mukai H
The Journal of dermatology · 2010 · vol. 37(6) , pp. 545–549 · doi:10.1111/j.1346-8138.2010.00831.x · PMID:20536670 · W1548599885
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This case report describes a 37-year-old woman with umbilical cutaneous endometriosis, where immunohistochemical staining confirmed ectopic endometrial glands and interstitium, with CD10 expression in the interstitial cells proving useful for diagnosis.

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Abstract

Endometriosis is a condition in which endometrium or endometrium-like tissue grows in areas other than the endometrium and is often found within the pelvis such as in the uterus or ovary, but occasionally develops ectopically in the skin. In this paper, we report a case of cutaneous endometriosis in the umbilical region found in a 37-year-old woman with no history of pregnancy. The lesion was a brown, firm and elastic nodule, 9 mm x 7 mm in size, and caused bleeding as well as pain which increased during menstruation. Histopathological findings revealed that there were small and large glandular cavity structures in the dermis and the edematous interstitium around it. On immunohistochemical staining for estrogen and progesterone receptors, the cellular nuclei of glandular cavity walls were mainly found to be positive for both, and cells in the edematous interstitium around the glandular cavity were positive for CD10. Consequently, we diagnosed this case as cutaneous endometriosis in the umbilical region. CD10 was initially described as a tumor-specific antigen found in acute lymphoblastic leukemia. Recently, the usefulness of CD10 in diagnosing endometriosis in addition to various types of lymphoma or blood cancer has been confirmed, and in our case it also proved to be as useful as estrogen receptor or progesterone receptor in the definitive diagnosis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Neprilysin Skin Diseases Umbilicus Adult Endometriosis Endometriosis Female Humans Neprilysin Skin Diseases Skin Diseases Umbilicus

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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