Endometriosis and infertility Surgery and ART: An integrated approach for successful management

Maria Elisabetta Coccia, M Elisabetta Coccia, Coccia ME, Francesca Rizzello, Rizzello F, Cammilli F, F. Cammilli, Fiamma Cammilli, Bracco GL, Gian Luca Bracco, Scarselli G, Gianfranco Scarselli
European journal of obstetrics, gynecology, and reproductive biology · 2008 · vol. 138(1) , pp. 54–59 · doi:10.1016/j.ejogrb.2007.11.010 · PMID:18243485 · W1979034651
Observational OA: closed CC0 ⤵ 56 in-corpus citations
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This paper discusses the relationship between endometriosis and infertility, exploring potential mechanisms and current understanding of their connection.

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Abstract

OBJECTIVES: Laparoscopy is considered the gold standard for treatment of endometriosis. In vitro fertilization and embryo transfer (IVF-ET) is often used to treat women with infertility associated with endometriosis. The objective of the study was to evaluate the pregnancy rate after surgical treatment and to assess whether a combined approach with laparoscopic surgery followed by IVF-ET can improve the "overall" pregnancy rate. STUDY DESIGN: A retrospective observational study was carried out on 107 infertile patients who underwent laparoscopic surgery for endometriosis and came at follow-up for a period of time between 1 and 11 years. Sixty-seven patients who did not become pregnant after surgery subsequently underwent IVF-ET. RESULTS: The pregnancy rate achieved after the integrated laparoscopy-IVF approach was 56.1%. The pregnancy rate after surgery, was significantly lower (37.4%). The fecundity rate for spontaneous conceptions within 6 months of laparoscopy (23.2%) was significantly higher (P<0.05) than for the following intervals. The cumulative fecundity in women older than 35 years was significantly lower than in younger women. CONCLUSIONS: In patients with endometriosis-associated infertility, surgery followed by IVF-ET is more effective than surgery alone. When patients fail to conceive spontaneously, after a maximum of 1 year from laparoscopic surgery, IVF should be suggested.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Gynecologic Surgical Procedures Gynecologic Surgical Procedures Infertility, Female Reproductive Techniques, Assisted Reproductive Techniques, Assisted Adult Adult Embryo Transfer Embryo Transfer Endometriosis Endometriosis Endometriosis Female Female Fertilization in Vitro Fertilization in Vitro Humans Humans Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (18)

Cited by (50)

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License: CC0 · commercial use OK