Factors associated with pregnancy after in vitro fertilization in infertile patients with posterior deep pelvic endometriosis: A retrospective study

C. Rubod, Chrystèle Rubod, Rubod C, A. Fouquet, Fouquet A, Stéphanie Bartolo, S Bartolo, Bartolo S, Lepage J, J. Lepage, A. Capelle, Capelle A, C Lefebvre, Christine Lefebvre, Lefebvre C, E Kamus, Éric Kamus, Kamus E, D Dewailly, Dewailly D, Didier Dewailly, P Collinet, Pierre Collinet, Collinet P
Journal of gynecology obstetrics and human reproduction · 2018 · vol. 48(4) , pp. 235–239 · doi:10.1016/j.jogoh.2018.06.002 · PMID:29908951 · W2808300837
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This retrospective study investigated factors associated with pregnancy in infertile patients with posterior deep pelvic endometriosis undergoing in vitro fertilization.

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Abstract

IntroductionThe management of posterior deep endometriosis is not consensual. This is due to a great heterogeneity of data from the literature. Many series were small and overall, predictors of pregnancy were not all included and analyzed by multivariate analysis. We conducted this study to evaluate the factors associated with pregnancy during the first two in vitro fertilization (IVF) attempts in infertile women with posterior deep endometriosis.Material and methods230 women were included in this retrospective observational study, between January 1st, 2007 and September 30th, 2013, at the University Hospital of Lille. A large set of variables were recorded and their association with the chance of pregnancy was analyzed by multivariate analysis (MVA), including patients' features, endometriosis items, surgery procedures and IVF data.ResultsAfter 2 IVF attempts, 48.7% of the 230 women achieved a pregnancy, including 39.1% of ongoing pregnancies. Logistic regression analysis retained five variables significantly associated to the chance of pregnancy: oocyte retrieval number (OR=0.468 (0.296-0.739) p=0.001), age (OR=0.888 (0.811-0.974) p=0.011), single embryo transfer number (OR=1.494 (1.036-2.153) p=0.031), presence of a recto-uterine nodule (OR=0.454 (0.235-0.877) p=0.019) and IVF technique (OR=0.509 (0.272-0.951) p=0.034).ConclusionThe presence of a recto uterine nodule is associated with a lower chance of pregnancy after IVF. It has to be checked by prospective studies whether the finding of a recto-uterine nodule whose pejorative effect has not been reported so far should encourage to perform surgery before IVF in patients with deep endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fertilization in Vitro Infertility, Female Infertility, Female Adult Endometriosis Endometriosis Endometriosis Female Humans Infertility, Female Magnetic Resonance Imaging Oocyte Retrieval Peritoneal Diseases Peritoneal Diseases Peritoneal Diseases Peritoneal Diseases Pregnancy Pregnancy Rate Rectal Diseases

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