Impact of Surgery for Deep Endometriosis on the Outcomes of In Vitro Fertilization

In: Endometriosis-related Infertility · 2024 · pp. 223–228 · doi:10.1007/978-3-031-50662-8_17 · W4392309970
book-chapter OA: closed CC0
Full text JSON View on OpenAlex View at publisher
AI-generated summary by claude@2026-06+body, 2026-06-08

Surgery for deep endometriosis should not be first-line IVF treatment for asymptomatic patients, but may be necessary for pain, obstruction risk, or urinary tract issues before IVF.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text

This chapter reviews available studies on whether surgery for deep endometriosis (DE) affects in vitro fertilization (IVF) outcomes, noting that the evidence base is limited with scarce literature, few controlled studies, and no randomized controlled trials. Across included reports, the chapter concludes that surgical excision of DE should not be offered as first-line treatment in asymptomatic patients to improve IVF outcomes, but surgery may be needed beforehand in selected situations such as intolerance of pain after stopping hormonal therapy, risks of bowel obstruction/subocclusion during IVF and pregnancy, and in cases like hematosalpinx or hydroureter/hydronephrosis. A major caveat emphasized is the lack of robust controlled trials and the need for adequately powered randomized studies with sufficient follow-up. This paper is centrally about endometriosis — it specifically synthesizes evidence on how surgery for deep endometriosis influences IVF outcomes.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 4,427 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Abstract

This chapter summarizes the available studies on the impact of surgery for deep endometriosis (DE) on in vitro fertilization (IVF) outcomes. The literature is scarce, and there are few controlled studies with no randomized controlled trials. Based on this background, surgical excision of DE should not be offered as the first-line treatment in asymptomatic patients to improve the outcomes of IVF. However, surgical treatment of DE may be required before IVF in patients who do not tolerate pain after the discontinuation of hormonal therapies and during the ovarian stimulation, in those at risk of bowel occlusion or subocclusion during IVF and pregnancy, and in patients with hematosalpinx or hydroureter/hydronephrosis. Future randomized controlled trials with adequate power and follow-up are required to define the role of surgery for DE before IVF. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

Leonardi M, et al. When to do surgery and when not to do surgery for endometriosis: a systematic review and meta-analysis. J Minim Invasive Gynecol. 2020;27(2):390–407 e3. Ferrero S, Evangelisti G, Barra F. Current and emerging treatment options for endometriosis. Expert Opin Pharmacother. 2018;19(10):1109–25. Barra F, et al. Infertility in patients with bowel endometriosis. Best Pract Res Clin Obstet Gynaecol. 2020;71:161. Mazzocco MI, et al. Spontaneous hemoperitoneum in pregnancy: Italian prospective population-based cohort study. Acta Obstet Gynecol Scand. 2022;101:1220. Maggiore LRU, et al. A systematic review on endometriosis during pregnancy: diagnosis, misdiagnosis, complications and outcomes. Hum Reprod Update. 2016;22(1):70–103. Maggiore LRU, et al. Spontaneous Uroperitoneum and preterm delivery in a patient with bladder endometriosis. J Minim Invasive Gynecol. 2015;22(6):923–4. Surrey ES, Schoolcraft WB. Does surgical management of endometriosis within 6 months of an in vitro fertilization-embryo transfer cycle improve outcome? J Assist Reprod Genet. 2003;20(9):365–70. Bianchi PH, et al. Extensive excision of deep infiltrative endometriosis before in vitro fertilization significantly improves pregnancy rates. J Minim Invasive Gynecol. 2009;16(2):174–80. Capelle A, et al. Surgery for deep infiltrating endometriosis before in vitro fertilization: no benefit for fertility? Gynecol Obstet Fertil. 2015;43(2):109–16. Ballester M, et al. Prior colorectal surgery for endometriosis-associated infertility improves ICSI-IVF outcomes: results from two expert centres. Eur J Obstet Gynecol Reprod Biol. 2017;209:95–9. Stepniewska A, et al. Fertility and clinical outcome after bowel resection in infertile women with endometriosis. Reprod Biomed Online. 2010;20(5):602–9. Mounsambote L, et al. Deep infiltrative endometriosis without digestive involvement, what is the impact of surgery on in vitro fertilization outcomes? A retrospective study. Gynecol Obstet Fertil Senol. 2017;45(1):15–21. Rubod C, et al. Factors associated with pregnancy after in vitro fertilization in infertile patients with posterior deep pelvic endometriosis: aA retrospective study. J Gynecol Obstet Hum Reprod. 2019;48(4):235–9. Bendifallah S, et al. Colorectal endometriosis-associated infertility: should surgery precede ART? Fertil Steril. 2017;108(3):525–531 e4. Casals G, et al. Impact of surgery for deep infiltrative endometriosis before in vitro fertilization: a systematic review and meta-analysis. J Minim Invasive Gynecol. 2021;28(7):1303–1312 e5. Berlanda N, et al. The impact of IVF on deep invasive endometriosis. Eur J Obstet Gynecol Reprod Biol X. 2019;4:100073. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Ferrero, S., Camerini, G., Mikhail, E. (2024). Impact of Surgery for Deep Endometriosis on the Outcomes of In Vitro Fertilization. In: Ferrero, S. (eds) Endometriosis-related Infertility. Springer, Cham. https://doi.org/10.1007/978-3-031-50662-8_17 Download citation DOI: https://doi.org/10.1007/978-3-031-50662-8_17 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-50661-1 Online ISBN: 978-3-031-50662-8 eBook Packages: MedicineMedicine (R0)

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (15)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK