{"paper_id":"60e8f2b7-3ce0-4422-aa0f-cff204ed18a0","body_text":"Abstract\nThis chapter summarizes the available studies on the impact of surgery for deep endometriosis (DE) on in vitro fertilization (IVF) outcomes. The literature is scarce, and there are few controlled studies with no randomized controlled trials. Based on this background, surgical excision of DE should not be offered as the first-line treatment in asymptomatic patients to improve the outcomes of IVF. However, surgical treatment of DE may be required before IVF in patients who do not tolerate pain after the discontinuation of hormonal therapies and during the ovarian stimulation, in those at risk of bowel occlusion or subocclusion during IVF and pregnancy, and in patients with hematosalpinx or hydroureter/hydronephrosis. Future randomized controlled trials with adequate power and follow-up are required to define the role of surgery for DE before IVF.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nLeonardi M, et al. When to do surgery and when not to do surgery for endometriosis: a systematic review and meta-analysis. J Minim Invasive Gynecol. 2020;27(2):390–407 e3.\nFerrero S, Evangelisti G, Barra F. Current and emerging treatment options for endometriosis. Expert Opin Pharmacother. 2018;19(10):1109–25.\nBarra F, et al. Infertility in patients with bowel endometriosis. Best Pract Res Clin Obstet Gynaecol. 2020;71:161.\nMazzocco MI, et al. Spontaneous hemoperitoneum in pregnancy: Italian prospective population-based cohort study. Acta Obstet Gynecol Scand. 2022;101:1220.\nMaggiore LRU, et al. A systematic review on endometriosis during pregnancy: diagnosis, misdiagnosis, complications and outcomes. Hum Reprod Update. 2016;22(1):70–103.\nMaggiore LRU, et al. Spontaneous Uroperitoneum and preterm delivery in a patient with bladder endometriosis. J Minim Invasive Gynecol. 2015;22(6):923–4.\nSurrey ES, Schoolcraft WB. Does surgical management of endometriosis within 6 months of an in vitro fertilization-embryo transfer cycle improve outcome? J Assist Reprod Genet. 2003;20(9):365–70.\nBianchi PH, et al. Extensive excision of deep infiltrative endometriosis before in vitro fertilization significantly improves pregnancy rates. J Minim Invasive Gynecol. 2009;16(2):174–80.\nCapelle A, et al. Surgery for deep infiltrating endometriosis before in vitro fertilization: no benefit for fertility? Gynecol Obstet Fertil. 2015;43(2):109–16.\nBallester M, et al. Prior colorectal surgery for endometriosis-associated infertility improves ICSI-IVF outcomes: results from two expert centres. Eur J Obstet Gynecol Reprod Biol. 2017;209:95–9.\nStepniewska A, et al. Fertility and clinical outcome after bowel resection in infertile women with endometriosis. Reprod Biomed Online. 2010;20(5):602–9.\nMounsambote L, et al. Deep infiltrative endometriosis without digestive involvement, what is the impact of surgery on in vitro fertilization outcomes? A retrospective study. Gynecol Obstet Fertil Senol. 2017;45(1):15–21.\nRubod C, et al. Factors associated with pregnancy after in vitro fertilization in infertile patients with posterior deep pelvic endometriosis: aA retrospective study. J Gynecol Obstet Hum Reprod. 2019;48(4):235–9.\nBendifallah S, et al. Colorectal endometriosis-associated infertility: should surgery precede ART? Fertil Steril. 2017;108(3):525–531 e4.\nCasals G, et al. Impact of surgery for deep infiltrative endometriosis before in vitro fertilization: a systematic review and meta-analysis. J Minim Invasive Gynecol. 2021;28(7):1303–1312 e5.\nBerlanda N, et al. The impact of IVF on deep invasive endometriosis. Eur J Obstet Gynecol Reprod Biol X. 2019;4:100073.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG\nAbout this chapter\nCite this chapter\nFerrero, S., Camerini, G., Mikhail, E. (2024). Impact of Surgery for Deep Endometriosis on the Outcomes of In Vitro Fertilization. In: Ferrero, S. (eds) Endometriosis-related Infertility. Springer, Cham. https://doi.org/10.1007/978-3-031-50662-8_17\nDownload citation\nDOI: https://doi.org/10.1007/978-3-031-50662-8_17\nPublished:\nPublisher Name: Springer, Cham\nPrint ISBN: 978-3-031-50661-1\nOnline ISBN: 978-3-031-50662-8\neBook Packages: MedicineMedicine (R0)","source_license":"CC0","license_restricted":false}