PREDICTION OF PREGNANCY ONSET IN THE TREATMENT OF ENDOMETRIOSIS ASSOCIATED INFERTILITY

О. M. Yuzko, Bohdan Yu. Tofan
In: Clinical and experimental pathology · 2022 · vol. 21(2) · doi:10.24061/1727-4338.xxi.2.80.2022.11 · W4285496309
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This review analyzes modern endometriosis classifications and treatment methods to predict pregnancy onset in endometriosis-associated infertility, concluding that prediction remains challenging and optimal treatment strategies are still needed.

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This paper is a narrative literature review aimed at analyzing contemporary endometriosis classifications that could be used to forecast pregnancy onset in patients with endometriosis-associated infertility, and it describes major treatment approaches including laparoscopic surgery and assisted reproductive technologies. It highlights that systems such as established staging/classification frameworks (including the Endometriosis Fertility Index) are discussed as tools to predict pregnancy outcomes. The authors explicitly note that predicting pregnancy onset in this patient group remains complex, implying limitations in current evidence and the need for continued search for the optimal option. This paper is centrally about endometriosis — it focuses specifically on predicting pregnancy onset using endometriosis classifications in endometriosis-associated infertility.

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Abstract

The main data, that can predict the onset of pregnancy in the treatment of endometriosisassociated infertility, based on a literature review, are cited in the article. The articledescribes the principle methods for endometriosis- associated infertility treatment bymeans of laparoscopic surgery, subsidiary reproductive technologies, classifications ofendometriosis that can predict the onset of pregnancy.Objective – to analyze modern classifications of endometriosis, which can be used topredict the onset of pregnancy in endometriosis- associated infertility.Conclusion. The cited literature review certifies that prediction of the pregnancy onsetin patients with endometriosis- associated infertility remains to be a difficult task andconfirms expediency of the optimal variant search.
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ПРОГНОЗУВАННЯ НАСТАННЯ ВАГІТНОСТІ ПРИ ЛІКУВАННІ ЕНДОМЕТРІОЗ-АСОЦІЙОВАНОГО БЕЗПЛІДДЯ DOI: https://doi.org/10.24061/1727-4338.XXI.2.80.2022.11Ключові слова: ендометріоз, класифікації, індекс фертильності, лікування, допоміжні репродуктивні технології, безпліддяАнотація В статті наведені основні дані, які дозволяють прогнозувати настання вагітності прилікуванніендометріоз-асоційованого безпліддя напідставі огляду літературних джерел. Описані основні методи лікування ендометріоз-асоційованого безпліддя за допомогою лапароскопічної хірургії, допоміжних репродуктивних технологій, а також класифікації ендометріозу, за допомогою яких можна прогнозувати настання вагітності. Метароботи –здійснитианалізсучаснихкласифікаційендометріозу,задопомогою яких можна прогнозувати настання вагітності при ендометріоз-асоційованому безплідді. Висновок. Наведений огляд літератури засвідчує, що прогнозування настання вагітності в пацієнток з ендометріоз-асоційованим безпліддям залишається складним завданням та підтверджує доцільність продовження пошуку оптимального варіанта. Посилання US Department of Health and Human Services. Spotlight: What to Know About Endometriosis [Internet]. NICHD Archive; 2018[cited Apr 28]. Available from: https://www.nichd.nih.gov/ newsroom/resources/spotlight/031218-spotlight- endometriosis World Health Organization. Endometriosis [Internet]. Geneva: WHO; 2021[cited 2022 Apr 29]. Available from: https://www.who. int/news-room/fact-sheets/detail/endometriosis Hladchuk IZ. Yenin RV, Kuznietsova OS. Diahnostyka i khirurhichne likuvannia patsiientiv z hlybokym infil’tratyvnym endometriozom [Diagnosis and surgical treatment of patients with deep infiltrative endometriosis]. InterConf. 2021;67:317-26. doi: 51582/interconf.19-20.07.2021.034 (in Ukranian) Zaporozhan VM, Hladchuk IZ, Rozhkovs’ka NM, Wolans’ka AH, Kozhakov VL. Novi tekhnolohii u khirurhichnomu likuvanni hlybokoho infil’tratyvnoho i poverkhnevoho perytoneal’noho endometriozu [New technologies in surgical treatment of deep infiltrative and superficial peritoneal endometriosis]. Reproduktyvna endokrynolohiia. 2014;2:7-9. doi: 18370/2309-4117.2014.16.7-9 (in Ukranian) Singh SS, Suen MWH. Surgery for endometriosis: beyond medical therapies. Fertil Steril. 2017;107(3):549-554. doi: 10.1016/j. fertnstert.2017.01.001 Cranney R, Condous G, Reid S. An update on the diagnosis, surgical management, and fertility outcomes for women with endometrioma. Acta Obstet Gynecol Scand. 2017;96(6):633-43. doi: 10.1111/aogs.13114 Zondervan KT, Becker CM, Missmer SA. Endometriosis. N Engl J Med. 2020;382(13):1244-56. doi: 10.1056/nejmra1810764 Rolla E. Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment. F1000Res [Internet]. 2019[cited 2022 May 23];8:529. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480968/pdf/ f1000research-8-16126.pdf doi: 10.12688/f1000research.14817.1 Keckstein J, Becker CM, Canis M, Feki A, Grimbizis GF, et al. Recommendations for the surgical treatment of endometriosis. Part : deep endometriosis. Hum Reprod Open [Internet]. 2020[cited May 25];2020(1): hoaa002. Available from: https://www. ncbi.nlm.nih.gov/pmc/articles/PMC7013143/pdf/hoaa002.pdf doi: 1093/hropen/hoaa002 Saridogan E, Becker CM, Feki A, Grimbizis GF, Hummelshoj L, Keckstein J, et al. Recommendations for the Surgical Treatment of Endometriosis. Part 1: Ovarian Endometrioma. Hum Reprod Open [Internet]. 2017[cited 2022 May 29];2017(4): hox016. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277006/ pdf/hox016.pdf doi: 10.1093/hropen/hox016 Johnson NP, Hummelshoj L, Adamson GD, Keckstein J, Taylor HS, Abrao MS, et al. World Endometriosis Society consensus on the classification of endometriosis. Hum Reprod. 2017;32(2):315-24. doi: 10.1093/humrep/dew293 Tuttlies F, Keckstein J, Ulrich U, Possover M, Schweppe KW, Wustlich M, et al. ENZIAN-score, a classification of deep infiltrating endometriosis. Zentralbl Gynakol. 2005;127(5):275-81. doi: 10.1055/s-2005-836904 Aylamazyan EK, Yarmolinskaya MI, Molotkov AS, Tsitskarava DZ. Klassifikatsiya endometrioza [Classifications of endometriosis]. Zhurnal akusherstva i zhenskikh bolezney. 2017;66(2):77-92. doi: 17816/JOWD66277-92 (in Russian) Adamson GD, Pasta DJ. Endometriosis fertility index: the new, validated endometriosis staging system. Fertil Steril. ;94(5):1609-15. doi: 10.1016/j.fertnstert.2009.09.035 Adamson GD. Endometriosis Fertility Index: is it better than the present staging systems? Curr Opin Obstet Gynecol. ;25(3):186-92. doi: 10.1097/gco.0b013e32836091da Zeng C, Xu J, Zhou Y, Zhou Y, Zhu S, Xue Q. Reproductive Performance after Surgery for Endometriosis: Predictive Value of the Revised American Fertility Society Classification and the Endometriosis Fertility Index. Gynecol Obstet Invest. ;77(3):180-5. doi: 10.1159/000358390 Coccia ME, Rizzello F, Cammilli F, Bracco GL, Scarselli G. Endometriosis and infertility Surgery and ART: an integrated approach for successful management. Eur J Obstet Gynecol Reprod Biol. 2008;138(1):54-9. doi: 10.1016/j.ejogrb.2007.11.010 Kucheryna NS. Optymizatsiia laparoskopichnoho likuvannia khvorykh z apopleksiieiu yaiechnykiv [Optimization of laparoscopic treatment of patients with ovarian apoplexy] [avtoreferat]. Kharkiv; 2009. 20 p. (in Ukranian) Classification of endometriosis. The American Fertility Society. Fertil Steril. 1979;32(6):633-4. Revised American Fertility Society Classification of endometriosi: 1985. Fertil Steril. 1985;43(3):351-2. doi: 10.1016/ s0015-0282(16)48430-x Revised American society of reproductive medicine classification of endometriosis: 1996. Fertil Steril. 1997;67(5):817-21. doi: 1016/s0015-0282(97)81391-x Dankovych NO, Vorobei- Vykhivs’ka VM. Prychyny ta formy bezpliddia. Suchasni mozhlyvosti diahnostyky ta likuvannia [Causes and forms of infertility. Modern possibilities of diagnosis and treatment]. Zdorov’e zhenshchiny. 2013;3:192-7. (in Ukranian) Yuzko AM, Yuzko TA, Rudenko NG. Stan ta perspektyvy vykorystannia dopomizhnykh reproduktyvnykh tekhnolohii pry likuvanni bezpliddia v Ukraini [Status and prospects of the use of assisted reproductive technologies in the treatment of infertility in Ukraine]. Zdorov’e zhenshchiny. 2013;8:26-30. (in Ukranian) Avramenko NV. Vspomogatel’nye reproduktivnye tekhnologii [Assisted reproductive technologies]. Zaporožskij medicinskij žurnal. 2014;3:95-100. doi: 10.14739/2310-1210.2014.3.26056 (in Russian) Forouhari S, Ghaemi SZ. A survey of psychosexual disorders in infertile women referred to the Zeinabiee Infertility Center of Shiraz University of Medical Sciences. Res J Biol Sci. 2013;8(4):99-103. doi: 10.36478/rjbsci.2013.99.103 De Ziegler D, Borghese B, Chapron C. Endometriosis and Infertility: pathophysiology and management Review Article. Lancet. ;376(9742):730-8. doi: 10.1016/s0140-6736(10)60490-4 Dus’ IL, Kamlyuk AM. Lecheniya besplodiya, assotsiirovannogo s endometriozom, s primeneniem gonadotropin- rilizing gormona Lyuprayd depo [Treatment of infertility associated with endometriosis using gonadotropin- releasing hormone Lupride depot]. Medychni aspekty zdorov’ia zhinky. 2012;6-7:44-5. (in Russian) Becker CM, Bokor A, Heikinheimo O, Horne A, Jansen F, Kiesel L, et al. ESHRE guideline: endometriosis, Human Reproduction Open. 2022;2:26. doi: 10.1093/hropen/hoac009 ##submission.downloads## Опубліковано Номер Розділ Ліцензія Авторське право (c) 2022 O.M. Юзько, Б. Ю. Тофан Ця робота ліцензується відповідно до Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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