New serum biomarkers for detection of endometriosis using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Zheng N, Nengneng Zheng, N Zheng, Chunqin Pan, Pan C, C Pan, W. Liu, Liu W
The Journal of international medical research · 2011 · vol. 39(4) , pp. 1184–1192 · doi:10.1177/147323001103900406 · PMID:21986120 · W2317078460
Diagnostic accuracy OA: bronze CC0 ⤵ 20 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

Serum proteomic profiling using MALDI-TOF-MS and magnetic beads identified three specific mass-to-charge peaks that accurately distinguished patients with endometriosis from healthy controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

This study used proteomic fingerprint technology, combining nano-sized magnetic beads with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), to screen for potential protein biomarkers for the diagnosis of endometriosis. Serum proteins from 126 patients with endometriosis and 120 healthy controls were profiled and compared. Biomarker pattern software identified 46 discriminating mass-to-charge m/z ratio peaks that were related to endometriosis. The model constructed by the software, based on three of these peaks (m/z 5988.7, 7185.3 and 8929.8), generated excellent separation between the endometriosis and control groups. The sensitivity was 91.4% and the specificity 95.0%. Blind testing on a second series of serum samples from patients with endometriosis and healthy controls indicated a sensitivity of 89.3% and a specificity of 90.0%. Biomarkers for endometriosis can be discovered in serum by MALDI-TOF-MS in combination with nano-sized magnetic beads. The pattern of combined markers provides a powerful and reliable diagnostic method for endometriosis, with high sensitivity and specificity.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Biomarkers Biomarkers, Tumor Blood Proteins Endometriosis Proteomics Proteomics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Adult Adult Biomarkers Biomarkers Biomarkers, Tumor Biomarkers, Tumor Blood Proteins Blood Proteins Case-Control Studies Case-Control Studies Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (28)

Cited by (20)

Source provenance

europepmc
last seen: 2026-10-19T06:17:24.038039+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:09:27.188120+00:00
License: CC0 · commercial use OK