Increase in serum leptin concentrations among women with endometriosis during danazol and leuprolide depot treatments

I M Matalliotakis, Matalliotakis IM, Ioannis Matalliotakis, Y. Koumantaki, Koumantaki YG, Y G Koumantaki, M A Neonaki, Neonaki MA, M Neonaki, Goumenou AG, A G Goumenou, Anastasia G. Goumenou, G E Koumantakis, Georgios Koumantakis, Koumantakis GE, Kyriakou DS, Despina Kyriakou, D S Kyriakou, Koumantakis EE, E E Koumantakis, Evgenios Koumantakis
American journal of obstetrics and gynecology · 2000 · vol. 183(1) , pp. 58–62 · doi:10.1067/mob.2000.105900 · PMID:10920309 · W1981697328
Non-randomised trial OA: closed CC0 ⤵ 12 in-corpus citations
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This study observed an increase in serum leptin concentrations in women with endometriosis receiving danazol and leuprolide depot treatments.

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Abstract

OBJECTIVE: This study was undertaken to evaluate serum leptin concentrations in women with endometriosis during treatment with danazol and with leuprolide depot. STUDY DESIGN: Twenty patients aged 18 to 42 years with regular menses and documented pelvic endometriosis were recruited from a university hospital setting. Treatment was 200 mg danazol 3 times daily for 6 months or 3.75 mg leuprolide depot every 28 days for 6 months. Serum leptin concentrations were measured before, during, and after treatment. A single blood sample was taken from each of 10 control women without endometriosis for comparison. Serum leptin level was measured with a radioimmunoassay kit with human leptin, and analysis of variance and paired t tests were used for statistical analysis. RESULTS: Serum leptin levels were almost the same among women with endometriosis as in the control group. Leptin levels were higher among women with endometriosis during treatment with danazol and leuprolide(P <.001). Three months after treatment, leptin values remained moderately higher than before treatment. CONCLUSION: Danazol and leuprolide increased serum leptin levels. The mechanism of leptin increase is unclear. Further studies are needed to determine whether an adipogonadal axis exists.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Endometriosis Estrogen Antagonists Leptin Leuprolide Adolescent Adolescent Adult Adult Danazol Danazol Danazol Endometriosis Endometriosis Endometriosis Estrogen Antagonists Estrogen Antagonists Estrogen Antagonists Female

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References (27)

Cited by (12)

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