Animal model of uterine adenomyosis: induction of the lesion in rats by ectopic pituitary isografting
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⤵ 20 in-corpus citations
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Ectopic anterior pituitary gland grafting into the rat uterine lumen induced adenomyosis in six of eight rats after 12 months, suggesting a hormonal influence promotes the condition.
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Abstract
Adenomyosis is a benign pathologic disorder of the uterine endometrial tissues whereby endometrial components, such as glands and stroma, invade the myometrium. Transplantation of a single anterior pituitary gland into the uterine lumen induced adenomyosis in six of eight Wistar rats 12 months after the grafting. Adenomyotic changes were not observed in six sham-operated control rats. Electron microscopic observations indicated that cells of the inner layer of the myometrium were reduced in size and irregularly shaped in the areas bearing adenomyotic changes. In pituitary-grafted rats, healthy corpora lutea remained in the ovaries, whereas control rats had degenerating ovaries. These findings are consistent with the results of pituitary-grafted mice reported previously and support our assertion that a hormonal milieu induced by pituitary grafting is favorable for development of uterine adenomyosis.
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Cited by (20)
- Magnetic Resonance Imaging-guided Focused Ultrasound Surgery in a Swine Adenomyosis Model 2023
- Unveiling the Pathogenesis of Adenomyosis through Animal Models 2022
- The effects of prolactin receptor blockade in a murine endometriosis interna model 2022
- Animal Models of Adenomyosis 2020
- Differential expression and inhibitory effects of aquaporins on the development of adenomyosis 2020
- Benign Uterine Diseases 2019
- Drug Development in Endometriosis and Adenomyosis: It Takes More Than Just Good Science 2018
- Ultramicro-trauma in the endometrial-myometrial junctional zone and pale cell migration in adenomyosis 2015
- The Animal Model of Adenomyosis 2015
- Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis 2011
- Use of a murine endometriosis interna model for the characterization of compounds that effectively treat human endometriosis 2011
- Evaluation of the efficacy of a danazol-loaded intrauterine contraceptive device on adenomyosis in an ICR mouse model 2008
- Experimental adenomyosis 2006
- Histological Evaluation of the Induced Endometriosis in Rats, after Treatment with Dexamethasone 2006
- Ovarian adenomyoma following gonadotrophin treatment for infertility 2006
- Histological Evaluation of the Induced Endometriosis in Rats, after Treatment with Dexamethasone Evaluación Histológica de la Endometriosis Inducida en Ratas, Posterior al Tratamiento con Dexametasona 2006
- Adenomyosis: what is the impact on fertility? 2005
- Adenomyosis in the baboon is associated with primary infertility 2004
- Adenomyosis--a result of disordered stromal differentiation 2001
- Induction of endometriosis and adenomyosis by transvaginal pituitary transplantation in mice with and without natural killer cell activity 1998
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- openalex
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