Investigation of glutathione concentrations in peritoneal fluid from women with and without endometriosis

Grzegorz Polak, Polak G, Iwona Wertel, Kozioł-Montewka M, Maria Kozioł-Montewka, Tarkowski R, Rafał Tarkowski, Jan Kotarski, Kotarski J
European journal of obstetrics, gynecology, and reproductive biology · 2003 · vol. 109(2) , pp. 206–208 · doi:10.1016/s0301-2115(03)00076-9 · PMID:12860343 · W2096029489
Non-randomised trial OA: closed CC0 ⤵ 5 in-corpus citations
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This study found no significant difference in peritoneal fluid glutathione concentrations between women with and without endometriosis, suggesting glutathione is not involved in disease progression.

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Abstract

UNLABELLED: Changes in the peritoneal fluid (PF) environment have been implicated in the pathogenesis of endometriosis as well as in the decrease of fertility. OBJECTIVE: To evaluate the concentration of glutathione in PF of women with endometriosis. PATIENTS: Twenty-one patients with endometriosis (I or II rAFS stage, n=11; III or IV rAFS stage, n=10), and 29 patients with follicular or dermoid ovarian cysts (n=17 and n=12, respectively). RESULTS: Mean (+/-S.D.) PF glutathione concentration was 0.22+/-0.01 micromol/ml in patients with minimal or mild endometriosis, 0.21+/-0.05 micromol/ml in women with III or IV stage of the disease, 0.24 +/- 0.03 micromol/ml in women with follicle ovarian cysts, and 0.23+/-0.05 micromol/ml in patients with dermoid tumors of ovaries. No significant difference in the peritoneal glutathione level was found between the groups. CONCLUSION: These results suggest that PF glutathione is not involved in the progression of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Dermoid Cyst Endometriosis Glutathione Ovarian Cysts Ovarian Neoplasms Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Biomarkers Biomarkers Biomarkers Dermoid Cyst Dermoid Cyst Dermoid Cyst Diagnosis, Differential Diagnosis, Differential Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (21)

Cited by (6)

SciLite annotations

chemicals 5
glutathione glutathione glutathione glutathione glutathione

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