Pituitary gonadotropin responsiveness with danazol
Lab / animal
OA: closed
CC0
⤵ 25 in-corpus citations
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This study investigated the effect of danazol administration on pituitary gonadotropin responsiveness in women.
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Abstract
Danazol (17alpha-pregn-4-en-20-yno-[2,3-d]isoxazol-17-ol) was administered daily for 4 days to castrated female rats. As previously demonstrated, danazol lowered serum levels of luteinizing hormone (LH) in an apparent dose-dependent fashion. Animals which received danazol in a dose sufficient to lower serum LH responded to administered LH-releasing hormone (LHRH) with increases in serum LH levels which were not diminished as compared with those of control animals. Although these experiments do not preclude an effect of danazol directly on the pituitary, the results indicate that this agent probably lowers serum LH primarily by inhibition of hypothalamic LHRH secretion.
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References (7)
- Clinical studies with an antigonadotropin-Danazol via openalex
- Danazol--a synthetic steroid derivative with interesting physiologic properties via openalex
- Pituitary and testicular function studies. I. Experience with a new gonadal inhibitor, 17-alpha-pregn-4-en-20-yno-(2,3-d)isoxazol-17-ol (Danazol) via openalex
- Treatment of endometriosis with an antigonadotropin, Danazol. A laparoscopic and histologic evaluation via openalex
- doi:10.1677/joe.0.0560155 via openalex
- doi:10.3181/00379727-128-33129 via openalex
- doi:10.1210/endo-97-2-493 via openalex
Cited by (25)
- Therapeutic effect and side effects of danazol in endometriosis 2010
- Effect of particle size on the prolonged action of subcutaneous danazol in male and female rats 2000
- Danazol: prolonged suppression of gonadotropins after subcutaneous administration in the castrate male rat 1994
- Effects of danazol on DNA synthesis in rat prostate 1993
- Effects of danazol on endometrial DNA synthesis in rats 1993
- Suppression of the development of uterine adenomyosis by danazol treatment in mice 1992
- Immunosuppressive effects of danazol in vitro 1987
- Danazol treatment of advanced prostate cancer: clinical and hormonal effects 1986
- Inhibition of gonadotropin-releasing hormone receptors in rat anterior pituitary monolayer cell cultures by danazol 1986
- Conservative treatment of endometriosis externa: the effects of danazol therapy 1985
- Danazol in the treatment of endometriosis: analysis of 100 cases with a 4-year follow-up 1985
- Danazol treatment of severely symptomatic fibrocystic breast disease and long-term follow-up--the Hjørring project 1984
- Endometriosis 1984
- Conservative treatment of endometriosis externa: the effects of danazol therapy 1983
- Effect of danazol on gonadal steroidogenesis in patients with a complete form of testicular feminization 1982
- Dynamic tests of hypothalamic and pituitary function in women treated with danazol 1982
- Danazol 1982
- Influence of 4-Hydroxyestradiol, Ethynylestradiol, Estradiol and Danazol on the LH-RH-induced Gonadotrophin Release in Ovariectomized Rats 1981
- Danazol suppression of luteinizing hormone secretion: a role for danazol-androgen receptor interaction within the brain-pituitary complex 1981
- Dosage aspects of danazol therapy in endometriosis: short-term and long-term effectiveness 1981
- In vitro effect of danazol on luteinizing hormone-releasing hormone-stimulated luteinizing hormone release in rat anterior pituitary cell cultures in vitro 1981
- Danazol: endocrine consequences in healthy women 1981
- Danazol binding and translocation of steroid receptors 1980
- Review: The mechanism of action of danazol, a novel steroid derivative 1980
- Danazol increasingly used. 1979
Source provenance
- openalex
- last seen: 2026-05-14T06:16:54.145842+00:00
- pubmed
- last seen: 2026-10-08T21:33:47.824698+00:00
- unpaywall
- last seen: 2026-09-17T06:32:46.214484+00:00
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